ArticleThe ocular surface2020
Comparison of clinical characteristics of post-refractive surgery-related and post-herpetic neuropathic corneal pain.
Article in The ocular surface, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Development and validation of a deep learning model for diagnosing neuropathic corneal pain via in vivo confocal microscopy.NPJ digital medicine · 2025Article
- Corneal neuropathic pain: a review to inform clinical practice.Eye (London, England) · 2024Review
- Corneal Neuropathic Pain: A Patient and Physician Perspective.Ophthalmology and therapy · 2024Article
- Herpes simplex keratitis: A brief clinical overview.World journal of virology · 2024Review
- Neuropathic Corneal Pain after Coronavirus Disease 2019 (COVID-19) Infection.Diseases (Basel, Switzerland) · 2024Article
- Corneal Nerve Abnormalities in Painful Dry Eye Disease Patients.Biomedicines · 2021Article
- Alterations in corneal nerves in different subtypes of dry eye disease: An in vivo confocal microscopy study.The ocular surface · 2021Article
- Entry receptor bias in evolutionarily distant HSV-1 clinical strains drives divergent ocular and nervous system pathologies.The ocular surface · 2021Article
- Ocular Surface Changes Associated with Ophthalmic Surgery.Journal of clinical medicine · 2021Review
- Morphological and Functional Changes of Corneal Nerves and Their Contribution to Peripheral and Central Sensory Abnormalities.Frontiers in cellular neuroscience · 2020Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo compare the clinical characteristics and in vivo confocal microscopy (IVCM) findings of patients with neuropathic corneal pain (NCP) due to refractive surgery (RS-NCP) and herpetic eye disease (H-NCP) to controls.
methodsSixteen patients with RS-NCP and 7 patients with H-NCP, and 37 healthy reference age- and sex-matched healthy controls were included to the study. The medical records were reviewed for demographic features, detailed disease history, ocular surface disease index (OSDI), ocular pain assessment survey (OPAS) scores. IVCM images of patients were analyzed and compared to reference controls by two masked observers.
resultsThe mean pain intensity score for the last 24 h (5.1 ± 2.4 vs. 3.9 ± 1.2; p = 0.27), last 2 weeks (6.1 ± 2.5 vs. 4.8 ± 2.3; p = 0.13) for RS-NCP vs. H-NCP respectively, and quality of life scores (p = 0.23) were similar in both groups. Quality of life, especially mood (p = 0.06) and enjoying life/relations to others (p = 0.10) were affected in both groups, but were not statistically significant between groups. The mean total nerve density was lower in RS-NCP (5,702.4 ± 4,599.0 μm/mm
conclusionNeuropathic corneal pain patients due to refractive surgery show similar clinical characteristics, pain levels, quality of life impact, and IVCM findings as patients with NCP due to herpetic eye disease.
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