Evidence map›Paper›PMID 32707174›Full record

ArticleHeart rhythm2021

Sex-specific I

Adonis Z Wu, Mu Chen, Dechun Yin, Thomas H Everett, Zhenhui Chen, Michael Rubart, James N Weiss, Zhilin Qu, Peng-Sheng Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Small-conductance CaThe Journal of physiology · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Adonis Z WuKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Mu ChenKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Dechun YinKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Thomas H EverettKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Zhenhui ChenKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Michael RubartDepartment of Pediatrics, Riley Heart Research Center, Indiana University School of Medicine, Indianapolis, Indiana.
James N WeissDepartments of Medicine (Cardiology), Physiology, David Geffen School of Medicine at the University of California, Los Angeles, California.
Zhilin QuDepartments of Medicine (Cardiology), Physiology, David Geffen School of Medicine at the University of California, Los Angeles, California.
Peng-Sheng ChenKrannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: chenp@cshs.org.
Indiana University School of MedicineUniversity of California, Los Angeles · USCedars-Sinai Medical Center · US

Funding

SK Current, beta-3 adrenoceptor activation and Sex Differences in Ventricular ArrhythmogenesisR01HL139829 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI PENG-SHENG CHEN, ZHILIN QU · 2018 to 2026
$4.5M
Mitochondria and arrhythmogenic calicum cycling dynamics in the heartR01HL133294 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN, XIE, LAI-HUA · 2017 to 2020
$2.8M
High Resolution, Noninvasive Measurement and Functional Classification of Vagal Nerve Response Patterns in Relation to Gastroparesis Symptom Management using Gastric Electrical Stimulation TherapyOT2OD028183 · OD · PURDUE UNIVERSITY · PI CLEMENTS, ISAAC PERRY, EVERETT, THOMAS H · 2019 to 2021
$2.0M
Skin Sympathetic Nerve Activity and Cardiac ArrhythmiasR42DA043391 · NIDA · ARRHYTHMOTECH, LLC · PI EVERETT, THOMAS H · 2016 to 2017
$1.5M
Subcutaneous nerve stimulation for arrhythmia control.U18TR002208 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI CHEN, PENG-SHENG · 2017 to 2018
$1.4M
NCATS NIH HHS U18 TR002208NHLBI NIH HHS R01 HL133294NHLBI NIH HHS R01 HL139829NIDA NIH HHS R42 DA043391NIH HHS OT2 OD028183
6 · The paper itself

Abstract

backgroundFemale sex is a known risk factor for drug-induced long QT syndrome (diLQTS). We recently demonstrated a sex difference in apamin-sensitive small-conductance Ca

objectiveThe purpose of this study was to test the hypothesis that there is a sex difference in I

methodsWe evaluated the sex difference in ventricular repolarization in 15 male and 22 female Langendorff-perfused rabbit hearts with optical mapping techniques during atrial pacing. HMR1556 (slowly activating delayed rectifier K

resultsHMR1556, E4031, and ATX-II led to the prolongation of action potential duration at 80% repolarization (APD

conclusionWe conclude that I

Indexed as

AnimalsApaminDiagnostic ImagingDisease Models, AnimalFemaleHeart VentriclesLong QT SyndromeMaleMyocardiumPatch-Clamp TechniquesRabbitsSex FactorsSmall-Conductance Calcium-Activated Potassium ChannelsApaminSmall-Conductance Calcium-Activated Potassium ChannelsCalcium transientOptical mappingPotassium and late sodium currentsRepolarization reserveSK current

Identifiers

PMID32707174
PMCPMC7796981
OpenAlexW3044058251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.