Evidence map›Paper›PMID 32707119›Full record

ReviewThe lancet. Diabetes & endocrinology2020

Endocrine-disrupting chemicals: economic, regulatory, and policy implications.

Christopher D Kassotis, Laura N Vandenberg, Barbara A Demeneix, Miquel Porta, Remy Slama, Leonardo Trasande

Open access · greenAbstract readReview
In one paragraph

Review in The lancet. Diabetes & endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 3 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 3 syntheses or guidelines pooled it, 251 citations in OpenAlex.

  1. A Review of Biomonitoring for Atrazine and Atrazine Metabolites Using Blood, Urine, and Sweat-Based Assays.International journal of environmental research and public health · 2026
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 3 countries.

Christopher D KassotisNicholas School of the Environment, Duke University, Durham, NC, USA.
Laura N VandenbergSchool of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA.
Barbara A DemeneixCentre National de la Recherche Scientifique, UMR 7221, Muséum National d'Histoire Naturelle, Paris, France; Université Paris-Sorbonne, Paris, France.
Miquel PortaHospital del Mar Medical Research Institute, PSMAR, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Barcelona, Spain; School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
Remy SlamaTeam of Environmental Epidemiology applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences, INSERM, U1209, CNRS, UMR 5309, Université Grenoble Alpes, Grenoble, France.
Leonardo TrasandeDepartment of Pediatrics, Environmental Medicine, and Population Health, New York University Grossman School of Medicine, New York, NY, USA; NYU College of Global Public Health, New York, NY, USA. Electronic address: leonardo.trasande@nyulangone.org.
Duke University · USHospital Del Mar · ESNew York University · USUniversité Grenoble Alpes · FRUniversité Sorbonne Nouvelle · FRUniversity of Massachusetts Amherst · US

Funding

RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX · 1985 to 2020
$26.1M
Repair of Carcinogen Damaged DNA in Human ChromatinR37ES002614 · NIEHS · WASHINGTON STATE UNIVERSITY · PI SMERDON, MICHAEL J · 2001 to 2010
$4.0M
Metabolomics Administrative Supplement: Disruption of parity-induced tumor suppressor pathways by xenoestrogen exposures during pregnancyU01ES026140 · NIEHS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI JERRY, D. JOSEPH, SCHNEIDER, SALLIE SMITH · 2015 to 2019
$3.7M
Preconceptual Bisphenol and Phthalate Effects on Early Embryonic DevelopmentR01ES029779 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRASANDE, LEONARDO · 2018 to 2023
$2.7M
Phthalates, BPA, Trajectories of In and Ex Utero Growth and Cardiometabolic RisksR01ES022972 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRASANDE, LEONARDO · 2014 to 2018
$2.7M
REPAIR OF CARCINOGEN-DAMAGED DNA IN HUMAN CHROMATINR01ES002614 · NIEHS · WASHINGTON STATE UNIVERSITY · PI SMERDON, MICHAEL J, WYRICK, JOHN J · 1985 to 2015
$2.5M
Environmental Oxidant Stressors in Pediatric Chronic Kidney Disease - ResubmissioR01DK100307 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRACHTMAN, HOWARD, TRASANDE, LEONARDO · 2014 to 2018
$2.5M
Impact of Environmental Estrogens on Sexually Dimorphic Development of the Mouse Mammary GlandK22ES025811 · NIEHS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI VANDENBERG, LAURA N. · 2015 to 2017
$445k
Mechanisms of Environmental-Mixture Induced Metabolic DisruptionK99ES030405 · NIEHS · DUKE UNIVERSITY · PI KASSOTIS, CHRISTOPHER DENNIS · 2019 to 2020
$199k
NIDDK NIH HHS R01 DK100307NIEHS NIH HHS K22 ES025811NIEHS NIH HHS K99 ES030405NIEHS NIH HHS P30 ES000260NIEHS NIH HHS R01 ES002614NIEHS NIH HHS R01 ES022972NIEHS NIH HHS R01 ES029779NIEHS NIH HHS U01ES02614NIEHS NIH HHS U01 ES026140
6 · The paper itself

Abstract

Endocrine-disrupting chemicals (EDCs) substantially cost society as a result of increases in disease and disability but-unlike other toxicant classes such as carcinogens-have yet to be codified into regulations as a hazard category. This Series paper examines economic, regulatory, and policy approaches to limit human EDC exposures and describes potential improvements. In the EU, general principles for EDCs call for minimisation of human exposure, identification as substances of very high concern, and ban on use in pesticides. In the USA, screening and testing programmes are focused on oestrogenic EDCs exclusively, and regulation is strictly risk-based. Minimisation of human exposure is unlikely without a clear overarching definition for EDCs and relevant pre-marketing test requirements. We call for a multifaceted international programme (eg, modelled on the International Agency for Research in Cancer) to address the effects of EDCs on human health-an approach that would proactively identify hazards for subsequent regulation.

Indexed as

Endocrine DisruptorsEnvironmental ExposureEnvironmental PollutantsHealth PolicyHumansEndocrine DisruptorsEnvironmental Pollutants

Identifiers

PMID32707119
PMCPMC7437819
OpenAlexW3044045346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.