Evidence map›Paper›PMID 32707076›Full record

ArticleStem cell reports2020

Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH

Aida Sarmiento-Castro, Eva Caamaño-Gutiérrez, Andrew H Sims, Nathan J Hull, Mark I James, Angélica Santiago-Gómez, Rachel Eyre, Christopher Clark, Martha E Brown, Michael D Brooks and 4 more

Open access · goldAbstract read
In one paragraph

Article in Stem cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

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  17. Tumor Dormancy: Implications for Invasion and Metastasis.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Aida Sarmiento-CastroManchester Breast Centre, Division of Cancer Sciences, University of Manchester, Manchester M20 4GJ, UK.
Eva Caamaño-GutiérrezTechnology Directorate, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.
Andrew H SimsApplied Bioinformatics of Cancer Group, University of Edinburgh Cancer Research UK Centre, Edinburgh EH4 2XR, UK.
Nathan J HullManchester Breast Centre, Division of Cancer Sciences, University of Manchester, Manchester M20 4GJ, UK.
Mark I JamesManchester Breast Centre, Division of Cancer Sciences, University of Manchester, Manchester M20 4GJ, UK.
Angélica Santiago-GómezManchester Breast Centre, Division of Cancer Sciences, University of Manchester, Manchester M20 4GJ, UK.
Rachel EyreManchester Breast Centre, Division of Cancer Sciences, University of Manchester, Manchester M20 4GJ, UK.
Christopher ClarkManchester Breast Centre, Division of Cancer Sciences, University of Manchester, Manchester M20 4GJ, UK.
Martha E BrownComprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Michael D BrooksComprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Max S WichaComprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Sacha J HowellManchester Breast Centre, Division of Cancer Sciences, University of Manchester, Manchester M20 4GJ, UK.
Robert B ClarkeManchester Breast Centre, Division of Cancer Sciences, University of Manchester, Manchester M20 4GJ, UK. Electronic address: robert.clarke@manchester.ac.uk.
Bruno M SimõesManchester Breast Centre, Division of Cancer Sciences, University of Manchester, Manchester M20 4GJ, UK. Electronic address: bruno.simoes@manchester.ac.uk.
University of Manchester · GBUniversity of Michigan · USEdinburgh Cancer Research · GBUniversity of Liverpool · GB

Funding

Targeting breast cancer stem cellsR35CA197585 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WICHA, MAX S. · 2016 to 2022
$6.4M
National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/T001267/1NCI NIH HHS R35 CA197585
6 · The paper itself

Abstract

Estrogen-receptor-positive breast tumors are treated with anti-estrogen (AE) therapies but frequently develop resistance. Cancer stem cells (CSCs) with high aldehyde dehydrogenase activity (ALDH

Indexed as

Aldehyde Dehydrogenase 1 FamilyBreast NeoplasmsCell Line, TumorDrug Resistance, NeoplasmEstrogen AntagonistsFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansNeoplasm MetastasisNeoplastic Stem CellsReceptors, Interleukin-1Single-Cell AnalysisTranscriptomeAldehyde Dehydrogenase 1 FamilyEstrogen AntagonistsReceptors, Interleukin-1ALDH(+) cellsanti-estrogensbreast cancer stem cellsdormancyIL1R1

Identifiers

PMID32707076
PMCPMC7419713
OpenAlexW3036180163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.