Evidence map›Paper›PMID 32707075›Full record

ArticleStem cell reports2020

Imaging Transplanted Photoreceptors in Living Nonhuman Primates with Single-Cell Resolution.

Ebrahim Aboualizadeh, M Joseph Phillips, Juliette E McGregor, David A DiLoreto, Jennifer M Strazzeri, Kamal R Dhakal, Brittany Bateman, Lindsey D Jager, Kelsy L Nilles, Sara A Stuedemann and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Animal models for the evaluation of retinal stem cell therapies.Progress in retinal and eye research · 2025
    Review
  9. Review
  10. Cellular and circuit remodeling of the primate foveal midget pathway after acute photoreceptor loss.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Ebrahim AboualizadehCenter for Visual Science, University of Rochester, Rochester, NY, USA.
M Joseph PhillipsWaisman Center, University of Wisconsin, Madison, WI, USA; McPherson Eye Research Institute, University of Wisconsin, Madison, WI, USA.
Juliette E McGregorCenter for Visual Science, University of Rochester, Rochester, NY, USA.
David A DiLoretoCenter for Visual Science, University of Rochester, Rochester, NY, USA; Flaum Eye Institute, University of Rochester, Rochester, NY, USA.
Jennifer M StrazzeriCenter for Visual Science, University of Rochester, Rochester, NY, USA; Flaum Eye Institute, University of Rochester, Rochester, NY, USA.
Kamal R DhakalCenter for Visual Science, University of Rochester, Rochester, NY, USA.
Brittany BatemanFlaum Eye Institute, University of Rochester, Rochester, NY, USA.
Lindsey D JagerWaisman Center, University of Wisconsin, Madison, WI, USA.
Kelsy L NillesWaisman Center, University of Wisconsin, Madison, WI, USA.
Sara A StuedemannWaisman Center, University of Wisconsin, Madison, WI, USA.
Allison L LudwigWaisman Center, University of Wisconsin, Madison, WI, USA.
Jennifer J HunterCenter for Visual Science, University of Rochester, Rochester, NY, USA; Flaum Eye Institute, University of Rochester, Rochester, NY, USA; The Institute of Optics, University of Rochester, Rochester, NY, USA.
William H MeriganCenter for Visual Science, University of Rochester, Rochester, NY, USA; Flaum Eye Institute, University of Rochester, Rochester, NY, USA.
David M GammWaisman Center, University of Wisconsin, Madison, WI, USA; McPherson Eye Research Institute, University of Wisconsin, Madison, WI, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA.
David R WilliamsCenter for Visual Science, University of Rochester, Rochester, NY, USA; The Institute of Optics, University of Rochester, Rochester, NY, USA. Electronic address: david.williams@rochester.edu.
University of Rochester · USUniversity of Wisconsin–Madison · USSmith-Kettlewell Eye Research Institute · US

Funding

VISUAL SCIENCE RESEARCH CTR SUPPORTP30EY001319 · NEI · UNIVERSITY OF ROCHESTER · PI MICHELE RUCCI · 1985 to 2026
$17.5M
Physiological and perceptual examination of vision restoration R01EY021166 · NEI · UNIVERSITY OF ROCHESTER · PI MERIGAN, WILLIAM H · 2011 to 2023
$8.4M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI CHANG, QIANG · 2016 to 2020
$6.0M
Accelerating vision restoration with in-vivo cellular imaging of retinal functionU01EY025497 · NEI · UNIVERSITY OF ROCHESTER · PI WILLIAMS, DAVID R · 2015 to 2019
$4.1M
Toward enhancing organization and defining synaptic connectivity of transplanted human pluripotent stem cell-derived photoreceptor graftsF30EY031230 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI LUDWIG, ALLISON LYN · 2020 to 2023
$163k
NEI NIH HHS F30 EY031230NEI NIH HHS P30 EY001319NEI NIH HHS R01 EY021166NEI NIH HHS U01 EY025497NICHD NIH HHS U54 HD090256
6 · The paper itself

Abstract

Stem cell-based transplantation therapies offer hope for currently untreatable retinal degenerations; however, preclinical progress has been largely confined to rodent models. Here, we describe an experimental platform for accelerating photoreceptor replacement therapy in the nonhuman primate, which has a visual system much more similar to the human. We deployed fluorescence adaptive optics scanning light ophthalmoscopy (FAOSLO) to noninvasively track transplanted photoreceptor precursors over time at cellular resolution in the living macaque. Fluorescently labeled photoreceptors generated from a CRX

Indexed as

AnimalsCell DifferentiationFluorescenceHumansLightModels, AnimalOptics and PhotonicsPhotoreceptor CellsPrimatesRetinaSingle-Cell AnalysisTomography, Optical Coherenceadaptive optics retinal imagingfluorescencehPSCintegration and survivalin vivononhuman primatesphotoreceptor precursorretinal degenerationstem cell therapyultrafast

Identifiers

PMID32707075
PMCPMC7419740
OpenAlexW3044994358

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.