ArticleCurrent biology : CB2020
Altered Hippocampal Place Cell Representation and Theta Rhythmicity following Moderate Prenatal Alcohol Exposure.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Assessment of GABANeuroscience letters · 2026Article
- Large-scale in vivo electrophysiology analysis reveals opposing thalamic and hippocampal excitability after third-trimester-equivalent alcohol exposure in mice.Journal of neurophysiology · 2026Article
- Epileptiform Discharges Drive Unique High-frequency Oscillations Within the Retrosplenial Cortex of Mice with Third Trimester Alcohol Exposure.bioRxiv : the preprint server for biology · 2026Article
- Unsupervised Phenotyping Reveals Disrupted Neural Firing Characteristics in the Anterior Thalamus and Surrounding Brain Regions Following Third-Trimester Equivalent Alcohol Exposure in Mice.bioRxiv : the preprint server for biology · 2025Article
- The effects of moderate prenatal alcohol exposure on performance in object and spatial discrimination tasks by adult male rats.Behavioural brain research · 2025Article
- Organization of spontaneous spatial behaviors under dark conditions is unaffected in adult male and female long-Evans rats after moderate prenatal alcohol exposure.Behavioral neuroscience · 2025Article
- Recent Investigations Designed to Unravel the Interaction of Age and Alcohol on Behavior and Cognition: Potential Neurobiological Mechanisms.Advances in experimental medicine and biology · 2025Review
- The Neurobiology of Learning and Memory in Rodent Models of Fetal Alcohol Spectrum Disorders.Advances in experimental medicine and biology · 2025Review
- The effects of moderate prenatal alcohol exposure on performance in hippocampal-sensitive spatial memory and anxiety tasks by adult male and female rat offspring.Alcohol (Fayetteville, N.Y.) · 2024Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.eLife · 2024Article
- The histamine HAlcohol (Fayetteville, N.Y.) · 2024Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.bioRxiv : the preprint server for biology · 2024Article
- Impact of two different rodent diets on maternal ethanol consumption, serum ethanol concentration and pregnancy outcome measures.Alcohol (Fayetteville, N.Y.) · 2023Article
- Unraveling the complex relationship between prenatal alcohol exposure, hippocampal LTP, and learning and memory.Frontiers in molecular neuroscience · 2023Review
- Dose-Related Reduction in Hippocampal Neuronal Populations in Fetal Alcohol Exposed Vervet Monkeys.Brain sciences · 2022Article
- Prenatal and postnatal insults differentially contribute to executive function and cognition: Utilizing touchscreen technology for perinatal brain injury research.Experimental neurology · 2022Article
- Sexually dimorphic organization of open field behavior following moderate prenatal alcohol exposure.Alcoholism, clinical and experimental research · 2022Article
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5 authors at 1 institution in 1 country.
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Abstract
Prenatal alcohol exposure (PAE) leads to profound deficits in spatial memory and synaptic and cellular alterations to the hippocampus that last into adulthood. Neurons in the hippocampus called place cells discharge as an animal enters specific places in an environment, establish distinct ensemble codes for familiar and novel places, and are modulated by local theta rhythms. Spatial memory is thought to critically depend on the integrity of hippocampal place cell firing. Therefore, we tested the hypothesis that hippocampal place cell firing is impaired after PAE by performing in vivo recordings from the hippocampi (CA1 and CA3) of moderate PAE and control adult rats. Our results show that hippocampal CA3 neurons from PAE rats have reduced spatial tuning. Second, CA1 and CA3 neurons from PAE rats are less likely to orthogonalize their firing between directions of travel on a linear track and between changes in contextual stimuli in an open arena compared to control neurons. Lastly, reductions in the number of hippocampal place cells exhibiting significant theta rhythmicity and phase precession were observed, which may suggest changes to hippocampal microcircuit function. Together, the reduced spatial tuning and sensitivity to contextual changes provide a neural systems-level mechanism to explain spatial memory impairment after moderate PAE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.