ArticleImmunity2020
Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3
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Article in Immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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68citing papers in PubMed
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Who cites it
68 citing papers in PubMed, 103 citations in OpenAlex.
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- Glucocorticoids regulate the human non-coding genome.bioRxiv : the preprint server for biology · 2025Article
- Intronic miR-342 is a key regulator of cellular glycolysis in Foxp3+ regulatory CD4 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
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- Inhibitory co-receptor Lag3 supports Foxp3Immunity · 2024Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 3 institutions in 1 country.
Dongkyun KimDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Quang Tam NguyenDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Juyeun LeeDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Sung Hwan LeeDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230.
Allison JanochaDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Sohee KimDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Hongnga T LeDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Nina DvorinaDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Kelly WeissDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Mark J CameronDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106.
Kewal AsosinghDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Serpil C ErzurumDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
William M BaldwinDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Ju-Seog LeeDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230.
Booki MinDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195. Electronic address: booki.min@northwestern.edu.
Cleveland Clinic · USThe University of Texas MD Anderson Cancer Center · USCase Western Reserve University · US
Funding
Targeting pathological hyaluronan matricesP01HL103453 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI REIZES, OFER · 2011 to 2020
$26.8MTissue Processing and Cell Culture COreP01HL081064 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ARONICA, MARK A · 2006 to 2019
$17.8MNITRIC OXIDE PRODUCTION AND REACTIONS IN THE LUNGR01HL060917 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Serpil C. Erzurum · 1999 to 2026
$6.3MAirway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2MNitric Oxide in Pulmonary HypertensionR37HL060917 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2009 to 2018
$3.9MThe role of IL-27/Lag3 axis in regulating Foxp3+ regulatory T cell functionR01AI125247 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Booki Min · 2017 to 2026
$3.4MFoxp3+ regulatory T cell-dependent treatment of allergic inflammation by glucocorticoidsR01AI147498 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MIN, BOOKI · 2019 to 2022
$2.2MNHLBI NIH HHS P01 HL081064NHLBI NIH HHS P01 HL103453NHLBI NIH HHS R01 HL060917NHLBI NIH HHS R37 HL060917NHLBI NIH HHS U10 HL109250NIAID NIH HHS R01 AI125247NIAID NIH HHS R01 AI147498
Abstract
Glucocorticoids (GC) are the mainstay treatment option for inflammatory conditions. Despite the broad usage of GC, the mechanisms by which GC exerts its effects remain elusive. Here, utilizing murine autoimmune and allergic inflammation models, we report that Foxp3
Indexed as
AnimalsAnti-Inflammatory AgentsDexamethasoneForkhead Transcription FactorsGlucocorticoidsInflammationMechanistic Target of Rapamycin Complex 2MiceMice, Inbred C57BLMicroRNAsRapamycin-Insensitive Companion of mTOR ProteinReceptors, GlucocorticoidT-Lymphocytes, RegulatoryAnti-Inflammatory AgentsDexamethasoneForkhead Transcription FactorsFoxp3 protein, mouseGlucocorticoidsMechanistic Target of Rapamycin Complex 2MicroRNAsMirn342 microRNA, mouseRapamycin-Insensitive Companion of mTOR ProteinReceptors, Glucocorticoidrictor protein, mouseallergic inflammationautoimmune inflammationglucocorticoidsmetabolismmiRNATreg cells
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