ArticleGenetics and molecular biology2020
Molecular evolution and diversification of the GRF transcription factor family.
Article in Genetics and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- SOT2/Growth-Regulating Factor 3 Modulates Salt Tolerance by Regulating Gibberellin-DELLA Signalling.Plant, cell & environment · 2026Article
- Genome-Wide Analysis of the GRF-GIF Module inInternational journal of molecular sciences · 2026Article
- Targeted Regulation ofPlants (Basel, Switzerland) · 2025Article
- The WRC domain of GRF transcription factors: Structure and DNA recognition.Protein science : a publication of the Protein Society · 2025Article
- Genome-wide identification and expression pattern analysis of the GRF transcription factor family in Astragalus mongholicus.Molecular biology reports · 2024Article
- Genome-Wide Analysis of Flax (International journal of molecular sciences · 2023Article
- Differential gene expression during floral transition in pineapple.Plant direct · 2023Article
- Comparatively Evolution and Expression Analysis of GRF Transcription Factor Genes in Seven Plant Species.Plants (Basel, Switzerland) · 2023Article
- Genome-wide identification ofFrontiers in plant science · 2023Article
- Genome-wide characterization and expression analysis of the growth-regulating factor family in Saccharum.BMC plant biology · 2022Article
- Functional conservation and divergence in plant-specificOpen life sciences · 2022Article
- Genome-wide identification and expression analysis of the growth regulating factor (GRF) family in Jatropha curcas.PloS one · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
- Growth Regulating Factors (GRFs) comprise a transcription factor family with important functions in plant growth and development. They are characterized by the presence of QLQ and WRC domains, responsible for interaction with proteins and DNA, respectively. The QLQ domain is named due to the similarity to a protein interaction domain found in the SWI2/SNF2 chromatin remodeling complex. Despite the occurrence of the QLQ domain in both families, the divergence between them had not been further explored. Here, we show evidence for GRF origin and determined its diversification in angiosperm species. Phylogenetic analysis revealed 11 well-supported groups of GRFs in flowering plants. These groups were supported by gene structure, synteny, and protein domain composition. Synteny and phylogenetic analyses allowed us to propose different sets of probable orthologs in the groups. Besides, our results, together with functional data previously published, allowed us to suggest candidate genes for engineering agronomic traits. In addition, we propose that the QLQ domain of GRF genes evolved from the eukaryotic SNF2 QLQ domain, most likely by a duplication event in the common ancestor of the Charophytes and land plants. Altogether, our results are important for advancing the origin and evolution of the GRF family in Streptophyta.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.