ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020
Mechanistic In Situ and Ex Situ Studies of Phase Transformations in Molecular Co-Crystals.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Mechanochemical Synthesis of New Praziquantel Cocrystals: Solid-State Characterization and Solubility.Crystal growth & design · 2024Article
- Polymorphic transitions in flufenamic acid-trehalose composites.International journal of pharmaceutics: X · 2023Article
- Mechanistic In Situ and Ex Situ Studies of Phase Transformations in Molecular Co-Crystals.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Co-crystallisation is widely explored as a route to improve the physical properties of pharmaceutical active ingredients, but little is known about the fundamental mechanisms of the process. Herein, we apply a hyphenated differential scanning calorimetry-X-ray diffraction technique to mimic the commercial hot melt extrusion process, and explore the heat-induced synthesis of a series of new co-crystals containing isonicotinamide. These comprise a 1:1 co-crystal with 4-hydroxybenzoic acid, 2:1 and 1:2 systems with 4-hydroxyphenylacetic acid and a 1:1 crystal with 3,4-dihydroxyphenylactic acid. The formation of co-crystals during heating is complex mechanistically. In addition to co-crystallisation, conversions between polymorphs of the co-former starting materials and co-crystal products are also observed. A subsequent study exploring the use of inkjet printing and milling to generate co-crystals revealed that the synthetic approach has a major effect on the co-crystal species and polymorphs produced.
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Registered trials
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