ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2020
Evaluating the effect of birth weight on brain volumes and depression: An observational and genetic study using UK Biobank cohort.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex differences in the effects of prematurity and/or low birthweight on neurodevelopmental outcomes: systematic review and meta-analyses.Biology of sex differences · 2023Pooled it
- Exposome-wide patterns predict brain health in aging.Nature communications · 2026Article
- Association and shared biological bases between birth weight and cortical structure.Translational psychiatry · 2025Article
- Sex-Specific Effects of Birth Weight on Longitudinal Behavioral Outcomes: A Mendelian Randomization Approach Using Polygenic Scores.Biological psychiatry global open science · 2024Article
- Association of birthweight and risk of incident dementia: a prospective cohort study.GeroScience · 2024Article
- Associations of Glucose Metabolism Status with Brain Macrostructure and Microstructure: Findings from the UK Biobank.The Journal of clinical endocrinology and metabolism · 2023Article
- Your height affects your health: genetic determinants and health-related outcomes in Taiwan.BMC medicine · 2022Article
- The Transition From Maternity Blues to Full-Blown Perinatal Depression: Results From a Longitudinal Study.Frontiers in psychiatry · 2021Article
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18 authors.
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Abstract
backgroundBirth weight influences not only brain development, but also mental health outcomes, including depression, but the underlying mechanism is unclear.
methodsThe phenotypic data of 12,872-91,009 participants (59.18-63.38% women) from UK Biobank were included to test the associations between the birth weight, depression, and brain volumes through the linear and logistic regression models. As birth weight is highly heritable, the polygenic risk scores (PRSs) of birth weight were calculated from the UK Biobank cohort (154,539 participants, 56.90% women) to estimate the effect of birth weight-related genetic variation on the development of depression and brain volumes. Finally, the mediation analyses of step approach and mediation analysis were used to estimate the role of brain volumes in the association between birth weight and depression. All analyses were conducted sex stratified to assess sex-specific role in the associations.
resultWe observed associations between birth weight and depression (odds ratio [OR] = 0.968, 95% confidence interval [CI] = 0.957-0.979, p = 2.29 × 10-6). Positive associations were observed between birth weight and brain volumes, such as gray matter (B = 0.131, p = 3.51 × 10-74) and white matter (B = 0.129, p = 1.67 × 10-74). Depression was also associated with brain volume, such as left thalamus (OR = 0.891, 95% CI = 0.850-0.933, p = 4.46 × 10-5) and right thalamus (OR = 0.884, 95% CI = 0.841-0.928, p = 2.67 × 10-5). Additionally, significant mediation effects of brain volume were found for the associations between birth weight and depression through steps approach and mediation analysis, such as gray matter (B = -0.220, p = 0.020) and right thalamus (B = -0.207, p = 0.014).
conclusionsOur results showed the associations among birth weight, depression, and brain volumes, and the mediation effect of brain volumes also provide evidence for the sex-specific of associations.
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