Evidence map›Paper›PMID 32706233›Full record

ArticleACS applied materials & interfaces2020

Systematic Study of Perfluorocarbon Nanoemulsions Stabilized by Polymer Amphiphiles.

Rachael A Day, Daniel A Estabrook, Carolyn Wu, John O Chapman, Alyssa J Togle, Ellen M Sletten

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Emerging Nanoplatforms are Effective Against Tumor Hypoxia.International journal of nanomedicine · 2026
    Review
  2. Article
  3. Nanotechnology-driven nanoemulsion gel for enhanced transdermal delivery ofFrontiers in bioengineering and biotechnology · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Shortwave Infrared Fluorofluorophores for Multicolor In Vivo Imaging.Angewandte Chemie (International ed. in English) · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Perfluorocarbon nanomaterials for photodynamic therapy.Current opinion in colloid & interface science · 2021
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rachael A DayDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.ORCID http://orcid.org/0000-0002-0018-7712
Daniel A EstabrookDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.ORCID http://orcid.org/0000-0001-7237-6291
Carolyn WuDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.
John O ChapmanDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.
Alyssa J TogleDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.
Ellen M SlettenDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.ORCID http://orcid.org/0000-0002-0049-7278

Funding

Biotechnology Training in Biomedical Sciences and EngineeringT32GM067555 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GU, ZHEN · 2005 to 2019
$2.8M
NIGMS NIH HHS T32 GM067555
6 · The paper itself

Abstract

Perfluorocarbon (PFC) nanoemulsions, droplets of fluorous solvent stabilized by surfactants dispersed in water, are simple yet versatile nanomaterials. The orthogonal nature of the fluorous phase promotes the formation of nanoemulsions through a simple, self-assembly process while simultaneously encapsulating fluorous-tagged payloads for various applications. The size, stability, and surface chemistry of PFC nanoemulsions are controlled by the surfactant. Here, we systematically study the effect of the hydrophilic portion of polymer surfactants on PFC nanoemulsions. We find that the hydrophilic block length and identity, the overall polymer hydrophilic/lipophilic balance, and the polymer architecture are all important factors. The ability to modulate these parameters enables control over initial size, stability, payload retention, cellular internalization, and protein adsorption of PFC nanoemulsions. With the insight obtained from this systematic study of polymer amphiphiles stabilizing PFC nanoemulsions, design features required for the optimal material are obtained.

Indexed as

AdsorptionAnimalsCattleEmulsionsEndocytosisFluorocarbonsHydrophobic and Hydrophilic InteractionsMiceNanostructuresPolymersRAW 264.7 CellsSerum Albumin, BovineSurface-Active AgentsEmulsionsFluorocarbonsPolymersSerum Albumin, BovineSurface-Active Agentsendocytosispayload releaseperfluorocarbon nanoemulsionpoly(2-oxazoline)polymer amphiphileprotein coronastability

Identifiers

PMID32706233
PMCPMC8341393

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.