ArticleMagnetic resonance in medicine2021
Ultra-high spatial resolution BOLD fMRI in humans using combined segmented-accelerated VFA-FLEET with a recursive RF pulse design.
Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Optimizing Selective RF Pulses for Enhanced Signal Stability in Turbo Spin Echo Using a Differentiable Extended Phase Graph Model.Magnetic resonance in medicine · 2026Article
- Large gains in SNR through the application of Shinnar-Le Roux RF pulse design to short-TR spin-echo fMRI acquisitions at 7 T.Magnetic resonance imaging · 2026Article
- Evaluating BOLD functional MRI biophysical simulation approaches: impact of vascular geometry, magnetic field calculations, and water diffusion models.bioRxiv : the preprint server for biology · 2025Article
- Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns.bioRxiv : the preprint server for biology · 2025Article
- Higher spatial resolution and sensitivity in whole brain functional MRI at 7T using 3D EPI accelerated with variable density CAIPI sampling and temporal random walk.Magnetic resonance in medicine · 2025Article
- Reduced physiology-induced temporal instability achieved with variable-flip-angle fast low-angle excitation echo-planar technique with multishot echo planar time-resolved imaging.Magnetic resonance in medicine · 2025Article
- Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- High-resolution motion- and phase-corrected functional MRI at 7 T using shuttered multishot echo-planar imaging.Magnetic resonance in medicine · 2023Article
- Time-encoded pseudo-continuous arterial spin labeling: Increasing SNR in ASL dynamic angiography.Magnetic resonance in medicine · 2023Article
- Two fine-scale channels for encoding motion and stereopsis within the human magnocellular stream.Progress in neurobiology · 2023Article
- Mapping of whole-cerebrum resting-state networks using ultra-high resolution acquisition protocols.Human brain mapping · 2022Article
- Pre-processing of Sub-millimeter GE-BOLD fMRI Data for Laminar Applications.Frontiers in neuroimaging · 2022Article
- New acquisition techniques and their prospects for the achievable resolution of fMRI.Progress in neurobiology · 2021Review
- LayNii: A software suite for layer-fMRI.NeuroImage · 2021Article
- High-resolution fMRI at 7 Tesla: challenges, promises and recent developments for individual-focused fMRI studies.Current opinion in behavioral sciences · 2021Article
- Scotopic Vision Is Selectively Processed in Thick-Type Columns in Human Extrastriate Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Evaluating BOLD functional MRI biophysical simulation approaches: Impact of vascular geometry, magnetic field calculations, and water diffusion models.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo alleviate the spatial encoding limitations of single-shot echo-planar imaging (EPI) by developing multi-shot segmented EPI for ultra-high-resolution functional MRI (fMRI) with reduced ghosting artifacts from subject motion and respiration. THEORY AND
methodsSegmented EPI can reduce readout duration and reduce acceleration factors, however, the time elapsed between segment acquisitions (on the order of seconds) can result in intermittent ghosting, limiting its use for fMRI. Here, "FLEET" segment ordering, where segments are looped over before slices, was combined with a variable flip angle progression (VFA-FLEET) to improve inter-segment fidelity and maximize signal for fMRI. Scaling a sinc pulse's flip angle for each segment (VFA-FLEET-Sinc) produced inconsistent slice profiles and ghosting, therefore, a recursive Shinnar-Le Roux (SLR) radiofrequency (RF) pulse design was developed (VFA-FLEET-SLR) to generate unique pulses for every segment that together produce consistent slice profiles and signals.
resultsThe temporal stability of VFA-FLEET-SLR was compared against conventional-segmented EPI and VFA-FLEET-Sinc at 3T and 7T. VFA-FLEET-SLR showed reductions in both intermittent and stable ghosting compared to conventional-segmented and VFA-FLEET-Sinc, resulting in improved image quality with a minor trade-off in temporal SNR. Combining VFA-FLEET-SLR with acceleration, we achieved a 0.6-mm isotropic acquisition at 7T, without zoomed imaging or partial Fourier, demonstrating reliable detection of blood oxygenation level-dependent (BOLD) responses to a visual stimulus. To counteract the increased repetition time from segmentation, simultaneous multi-slice VFA-FLEET-SLR was demonstrated using RF-encoded controlled aliasing.
conclusionsVFA-FLEET with a recursive RF pulse design supports acquisitions with low levels of artifact and spatial blur, enabling fMRI at previously inaccessible spatial resolutions with a "full-brain" field of view.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.