ArticleOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2020
Corneal tissue properties following scleral lens wear using Scheimpflug imaging.
Article in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Corneal and Intraocular Pressure Responses to Scleral Lens Wear: A Meta-Analysis.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Pooled it
- Influence of Room Illumination on Corneal Densitometry.Translational vision science & technology · 2026Article
- Combination of tissue-derived and shape-based parameters for subclinical keratoconus detection.Biomedical optics express · 2026Article
- Deep learning-based keratoconus detection from Scheimpflug images.Biomedical optics express · 2025Article
- A Method for Visualizing Corneal Dynamics Through Pixel Intensity Tracking.Translational vision science & technology · 2025Article
- Corneal tissue changes following short-term soft contact lens wear of different materials.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023Article
- Influence of eye tilt on corneal densitometry.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2022Article
- How Can We Best Measure the Performance of Scleral Lenses? Current Insights.Clinical optometry · 2022Review
- Suspect glaucoma detection from corneal densitometry supported by machine learning.Journal of optometry · 2022Article
- Scheimpflug-Based Analysis of the Reflectivity of the Cornea in Marfan Syndrome.Translational vision science & technology · 2021Article
- Detection of Subclinical Keratoconus With a Validated Alternative Method to Corneal Densitometry.Translational vision science & technology · 2021Article
- Corneal tissue properties following scleral lens wear using Scheimpflug imaging.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2020Article
Corrections and comments
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the effect of short-term scleral lens wear on the corneal stroma at a macroscopic (thickness) and microscopic (within tissue) level, including regional variations.
methodsFourteen young, healthy participants wore a rotationally symmetric, 16.5 mm diameter, scleral lens for 8 h. Scheimpflug images were captured before, and immediately after, lens wear, and also on a second day (without lens wear) to quantify natural corneal diurnal variations. After corneal segmentation, pixel intensities of the stromal tissue were statistically modelled using a Weibull probability density function from which parameters α and β were derived.
resultsBoth α and β parameters increased significantly following scleral lens wear (by 5.7 ± 10% and 6.5 ± 6.5%, respectively, both p < 0.01). Corneal thickness also increased slightly following lens wear (mean increase 0.49 ± 1.77%, p = 0.01); however, the change in α and β parameters did not correlate with the magnitude of corneal swelling. On the control day, small but significant corneal thinning was observed (-0.82 ± 1.1%, p = 0.03), while α and β parameters remained stable. Both microparameters varied significantly across the cornea, with α decreasing (-15.4 ± 0.7%) and β increasing towards the periphery (+4.4 ± 2.6%) (both p < 0.001).
conclusionCorneal microparameters α and β varied regionally across the cornea and displayed a statistically significant increase following short-term scleral lens wear, but remained stable between morning and evening measurements taken during a control day without lens wear. These corneal microparameters may be a useful metric to quantify subclinical corneal changes associated with low level hypoxia.
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