Evidence map›Paper›PMID 32705610›Full record

ReviewJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2020

A Network Meta-analysis of Surgery for Chronic Pancreatitis: Impact on Pain and Quality of Life.

Chathura B B Ratnayake, Sivesh K Kamarajah, Benjamin P T Loveday, Manu Nayar, Kofi Oppong, Steve White, Jeremy J French, John A Windsor, Sanjay Pandanaboyana

Abstract readReviewNetwork Meta-Analysis
PubMed Publisher
In one paragraph

Review in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Review
  5. Chronic pancreatitis: how does surgery step in?Frontiers in gastroenterology (Lausanne, Switzerland) · 2026
    Review
  6. Mechanism and treatment of pancreatic duct stones.World journal of gastrointestinal surgery · 2025
    Review
  7. Pain in chronic pancreatitis: What can we do today?World journal of methodology · 2024
    Review
  8. Review
  9. Determination of the Length of Pancreatic Ductotomy by Pancreaticoscopy During Frey's Procedure for Chronic Pancreatitis.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chathura B B RatnayakeDepartment of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0002-5188-9124
Sivesh K KamarajahDepartment of Hepatobiliary, Pancreatic and Transplant Surgery, Department of Surgery,, Freeman Hospital, Newcastle upon Tyne, UK.
Benjamin P T LovedayDepartment of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Manu NayarDepartment of Gastroenterology, Freeman Hospital, Newcastle upon Tyne, UK.
Kofi OppongDepartment of Gastroenterology, Freeman Hospital, Newcastle upon Tyne, UK.
Steve WhiteDepartment of Hepatobiliary, Pancreatic and Transplant Surgery, Department of Surgery,, Freeman Hospital, Newcastle upon Tyne, UK.
Jeremy J FrenchDepartment of Hepatobiliary, Pancreatic and Transplant Surgery, Department of Surgery,, Freeman Hospital, Newcastle upon Tyne, UK.
John A WindsorDepartment of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Sanjay PandanaboyanaDepartment of Hepatobiliary, Pancreatic and Transplant Surgery, Department of Surgery,, Freeman Hospital, Newcastle upon Tyne, UK. Sanjay.pandanaboyana@nuth.nhs.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe surgical operation associated with improved pain and quality of life (QoL) in patients with chronic pancreatitis (CP) is unknown.

methodThe Scopus, EMBASE, Medline and Cochrane databases were systematically searched until May 2019, and all randomised trials (RCTs) comparing surgical operations for CP pain were included in a network meta-analysis (NMA).

resultsFour surgical operations for treating CP were directly compared in eight RCTs including 597 patients. Patients were mainly male (79%, 474/597) with alcoholic CP (85%, 382/452). Surgical operations included were pancreatoduodenectomy (224, 38%), Berne procedure (168, 28%), Beger procedure (133, 22%) and Frey procedure (72, 12%). The NMA revealed that the Beger procedure ranked best for pain relief, whilst the Frey procedure ranked best for postoperative QoL, postoperative pancreatic fistula rate and postoperative exocrine insufficiency rate during a median follow-up of 26 months (reported range 6-58 months). Overall the Frey procedure ranked best for the combination of primary outcome measures based on surface under cumulative ranking curve scores.

conclusionsOverall the Frey procedure may perform the best for both pain relief and postoperative QoL in patients with CP. Further trials are warranted in defining the role of surgery in relation to endotherapy.

Indexed as

Pancreatitis, ChronicQuality of LifeHumansMalePainPancreatectomyTreatment OutcomeChronic pancreatitisPainPancreatectomyQuality of life

Identifiers

PMID32705610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.