Evidence map›Paper›PMID 32705457›Full record

ArticleJournal of neuro-oncology2020

Variations in attitudes towards stereotactic biopsy of adult diffuse midline glioma patients: a survey of members of the AANS/CNS Tumor Section.

John Lynes, Alvina A Acquaye, Hannah Sur, Anthony Nwankwo, Victoria Sanchez, Elizabeth Vera, Tianxia Wu, Brett Theeler, Terri S Armstrong, Mark R Gilbert and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

John LynesSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), 10 Center Drive, Room 3D20, Bethesda, MD, 20892, USA.
Alvina A AcquayeNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Hannah SurSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), 10 Center Drive, Room 3D20, Bethesda, MD, 20892, USA.
Anthony NwankwoSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), 10 Center Drive, Room 3D20, Bethesda, MD, 20892, USA.
Victoria SanchezSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), 10 Center Drive, Room 3D20, Bethesda, MD, 20892, USA.
Elizabeth VeraNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Tianxia WuClinical Trials Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Brett TheelerNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Terri S ArmstrongNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Mark R GilbertNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Edjah K NduomSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), 10 Center Drive, Room 3D20, Bethesda, MD, 20892, USA. edjah.nduom@nih.gov.ORCID http://orcid.org/0000-0001-9882-0899
National Institutes of Health · US

Funding

Molecular Pathogenesis of NeoplasiaZIANS003052 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HEISS, JOHN · 2009 to 2025
$20.7M
Clinical and Translational Investigations of Immune Suppression and Immune Modulation in GlioblastomaZIANS009418 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NDUOM, EDJAH · 2020 to 2024
$2.2M
NINDS NIH HHS Intramural Research Program
6 · The paper itself

Abstract

purposeDiffuse midline gliomas are rare midline CNS malignancies that primarily affect children but can also affect adults. While radiation is standard treatment, prognosis remains fatal. Furthermore, due to its sensitive anatomic location, many physicians have been reluctant to perform biopsies without potential for improved prognosis. However, recent advancements in molecular-targeted therapeutics have encouraged greater tissue sampling. While the literature reflects this progress, the landscape of how clinicians actually manage these patients remains unclear. Our goal was to assess the attitudes of current practicing neurosurgical oncologists towards management of adult diffuse midline gliomas, reasons behind their practices, and factors that might influence these practices.

methodsWe created and distributed a survey with 16 multiple choice and open-ended questions to members of the Tumor Section of the Congress of Neurological Surgeons.

resultsA total of 81 physicians responded to the survey. Although time since training and volume of glioma patients did not significantly affect the decision to consider clinical trials or to offer biopsy, those that operated on fewer gliomas (< 25/year) were more likely to cite surgical morbidity as the primary reason not to biopsy these midline locations. Further, surgeons with access to more advanced molecular testing were significantly more likely to consider clinical trial eligibility when offering biopsies.

conclusionFactors that affect the management of diffuse midline gliomas and the role of biopsy are relatively uniform across the field, however, there were a few notable differences that reflect the changes within the neuro-oncology field in response to clinical trials.

Indexed as

Attitude of Health PersonnelAdultBiopsyBrain NeoplasmsGliomaHumansNeurosurgeonsNeurosurgical ProceduresStereotaxic TechniquesSurveys and QuestionnairesAdult diffuse midline gliomaBiopsyBrain neoplasmGlioma

Identifiers

PMID32705457
PMCPMC7452882
OpenAlexW3045423274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.