ArticleAnnals of biomedical engineering2021
Structural Responses of Integrated Parametric Aortic Valve in an Electro-Mechanical Full Heart Model.
Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Analysis of fibrocalcific aortic valve stenosis: computational pre-and-post TAVR haemodynamics behaviours.Royal Society open science · 2024Article
- Fluid-structure interaction modeling of compliant aortic valves using the lattice Boltzmann CFD and FEM methods.Biomechanics and modeling in mechanobiology · 2023Article
- Fragmentation of Different Calcification Growth Patterns in Bicuspid Valves During Balloon Valvuloplasty Procedure.Annals of biomedical engineering · 2023Article
- Patient-Specific Analysis of Ascending Thoracic Aortic Aneurysm with the Living Heart Human Model.Bioengineering (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The aortic valve (AV) is located between the left ventricle and the aorta and responsible for maintaining an outward unidirectional flow. Many AV hemodynamic and structural aspects of have been extensively studied, however, more sophisticated models are needed to better understand the AV biomechanical behavior. This study deals with integrating a new parametric AV structural model with the electro-mechanical Living Heart Human Model® (LHHM). The LHHM is a finite element model simulating human heart capable of realistic electro-mechanical simulations. Different geometric metrics of AV have been examined. New integrated structural AV model within the LHHM better predict local stresses during the cardiac cycle due to the realistic boundary condition derived from the LHHM. It was found that ellipticity index (EI), calculated as the ratio between the maximal (Max) and minimal (Min) aortic annulus (AA) diameters, well correlates with measured clinical data obtained from patients undergoing computed tomography (CT) while the annular perimeter (Perim) matches the same trend. This increases the confidence in the predicted kinematic behavior, leaflets coaptation, and the overall stresses. From the clinical aspect, the new proposed coupled and integrated AV modeling can serve as a platform for design and implementation of pre-transcatheter aortic valve replacement (TAVR) procedures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.