Evidence map›Paper›PMID 32705338›Full record

ArticleArchives of gynecology and obstetrics2020

Maternal hepatitis B infection status and adverse pregnancy outcomes: a retrospective cohort analysis.

Kaiqi Wu, Hong Wang, Shuai Li, Hong Zhang, Bo Zhu

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Archives of gynecology and obstetrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. [Correlation between hepatitis B virus infection and adverse pregnancy outcomes-a systematic review and meta-analysis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
    Pooled it
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  9. Role of viral hepatitis in pregnancy and its triggering mechanism.Journal of translational internal medicine · 2024
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  11. Hepatitis B virus infection, infertility, and assisted reproduction.Journal of Zhejiang University. Science. B · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kaiqi Wu *School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, China.
Hong Wang *School of Medicine, Women's Hospital, Zhejiang University, Hangzhou, China.
Shuai LiSchool of Medicine, Women's Hospital, Zhejiang University, Hangzhou, China.
Hong ZhangSchool of Medicine, Women's Hospital, Zhejiang University, Hangzhou, China.
Bo ZhuSchool of Medicine, Women's Hospital, Zhejiang University, Hangzhou, China. 5202054@zju.edu.cn.ORCID http://orcid.org/0000-0002-4298-8788
Women's Hospital, School of Medicine, Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the association between maternal HBsAg-positive status and pregnancy outcomes.

methodsThe study enrolled women with singleton pregnancies who delivered during January-December 2018. Data of maternal demographics and main adverse pregnancy outcomes were collected from the institutional medical records and analyzed by univariate and multivariate logistic regression models to determine the association between maternal HBV markers (HBsAg/HBeAg/HBV-DNA loads status) and adverse pregnancy outcomes.

resultsTotal 1146 HBsAg-positive and 18,354 HBsAg-negative pregnant women were included. After adjusting for potential confounding variables, maternal HBsAg-positive status was associated with a high risk of gestational diabetes mellitus (GDM) [adjusted odds ratio (aOR) = 1.24; 95% confidence interval (CI) 1.07-1.43], intrahepatic cholestasis of pregnancy (ICP) (aOR = 3.83; 95% CI 3.14-4.68), preterm birth (aOR = 1.42; 95% CI 1.17-1.72), and neonatal asphyxia (aOR = 2.20; 95% CI 1.34-3.63). Further, higher risks of ICP and neonatal asphyxia remained with either HBeAg-positive status (aOR = 1.64; 95% CI 1.10-2.44; aOR = 3.08; 95% CI 1.17-8.00) or high HBV-DNA load during the second trimester (aOR = 1.52; 95% CI 1.06-2.35; aOR = 4.20; 95% CI 4.20-15.83) among HBsAg-positive pregnant women.

conclusionWomen with maternal HBsAg-positive status may have increased risks of GDM, ICP, preterm birth, and neonatal asphyxia; furthermore, the risks of ICP and neonatal asphyxia were higher in women with HBeAg-positive status and a high HBV-DNA load during the second trimester among the HBsAg-positive pregnant women, implying that careful surveillance for chronic HBV infection during pregnancy is warranted.

Indexed as

AdultCholestasis, IntrahepaticDiabetes, GestationalFemaleHepatitis BHepatitis B e AntigensHepatitis B Surface AntigensHepatitis B virusHumansInfant, NewbornPregnancyPregnancy ComplicationsPregnancy Complications, InfectiousPregnancy OutcomePregnant PeoplePremature BirthHepatitis B e AntigensHepatitis B Surface AntigensHepatitis B virus infectionIntrahepatic cholestasis of pregnancyNeonatal asphyxiaPregnancy outcomes

Identifiers

PMID32705338
OpenAlexW3044732095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.