Evidence map›Paper›PMID 32705327›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021

Spectrum of neuroimaging findings post-proton beam therapy in a large pediatric cohort.

Debarata Bhattacharya, Sahil Chhabda, Rahul Lakshmanan, Ronald Tan, Richard Warne, Massimo Benenati, Anthony Michalski, Kristian Aquilina, Thomas Jacques, Darren Hargrave and 3 more

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Relative biological effectiveness and neural stem cell fate in carbon ion-irradiated human brain organoids.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Debarata BhattacharyaRoyal Victoria Hospital, Belfast, UK.
Sahil ChhabdaGreat Ormond Street Hospital, London, UK.
Rahul LakshmananPerth Children's Hospital, Perth, Australia.
Ronald TanKK Women's and Children's Hospital, Singapore, Singapore.
Richard WarnePerth Children's Hospital, Perth, Australia.
Massimo BenenatiUniversita Cattolica del Sacro Cuore, Rome, Italy.
Anthony MichalskiGreat Ormond Street Hospital, London, UK.
Kristian AquilinaGreat Ormond Street Hospital, London, UK.
Thomas JacquesUCL Great Ormond Street Institute of Child Health, London, UK.
Darren HargraveGreat Ormond Street Hospital, London, UK.
Yen-Ching ChangUniversity College London Hospital, London, UK.
Jenny GainsUniversity College London Hospital, London, UK.
Kshitij MankadGreat Ormond Street Hospital, London, UK. Kshitij.mankad@gosh.nhs.uk.ORCID 0000-0001-5979-9337
Great Ormond Street Hospital · GBPrincess Margaret Hospital for Children · AUUniversity College Hospital · GBKK Women's and Children's Hospital · SGUniversità Cattolica del Sacro Cuore · ITUniversity of Ulster · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeProton beam therapy (PBT) is now well established for the treatment of certain pediatric brain tumors. The intrinsic properties of PBT are known to reduce long-term negative effects of photon radiotherapy (PRT). To better understand the intracranial effects of PBT, we analyzed the longitudinal imaging changes in a cohort of children with brain tumors treated by PBT with clinical and radiotherapy dose correlations. MATERIALS AND

methodsRetrospective imaging review of 46 patients from our hospital with brain tumors treated by PBT. The imaging findings were correlated with clinical and dose parameters.

resultsImaging changes were assessed by reviewing serial magnetic resonance imaging (MRI) scans following PBT over a follow-up period ranging from 1 month to 7 years. Imaging changes were observed in 23 patients undergoing PBT and categorized as pseudoprogression (10 patients, 43%), white matter changes (6 patients, 23%), parenchymal atrophy (6 patients, 23%), and cerebral large vessel arteriopathy (5 patients, 25%). Three patients had more than one type of imaging change. Clinical symptoms attributable to PBT were observed in 13 (28%) patients.

conclusionIn accordance with published literature, we found evidence of varied intracranial imaging changes in pediatric brain tumor patients treated with PBT. There was a higher incidence (10%) of large vessel cerebral arteriopathy in our cohort than previously described in the literature. Twenty-eight percent of patients had clinical sequelae as a result of these changes, particularly in the large vessel arteriopathy subgroup, arguing the need for angiographic and perfusion surveillance to pre-empt any morbidities and offer potential neuro-protection.

Indexed as

Brain NeoplasmsProton TherapyChildCohort StudiesHumansNeuroimagingRetrospective StudiesBrain tumorLarge vessel arteriopathyPediatricPhoton radiotherapyProton beam therapyPseudoprogressionRadiation necrosis

Identifiers

PMID32705327
OpenAlexW3044525992

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.