ArticleInternational journal of molecular medicine2020
Co‑expression of peripheral olfactory receptors with SARS‑CoV‑2 infection mediators: Potential implications beyond loss of smell as a COVID‑19 symptom.
Article in International journal of molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Effects of SARS-CoV-2 Vaccines on Sperm Quality: Systematic Review.JMIR public health and surveillance · 2023Pooled it
- The Spike of SARS-CoV-2: Uniqueness and Applications.Frontiers in immunology · 2021Pooled it
- Pathophysiological relationship between COVID-19 and olfactory dysfunction: A systematic review.Brazilian journal of otorhinolaryngologyPooled it
- Effects of Asprosin and Role of TLR4 as a Biomarker in Endometrial Cancer.Molecules (Basel, Switzerland) · 2025Article
- Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment.Foods (Basel, Switzerland) · 2024Review
- Impaired metal perception and regulation of associated human foliate papillae tongue transcriptome in long-COVID-19.Scientific reports · 2024Article
- Article
- Article
- Review on acute pancreatitis attributed to COVID-19 infection.World journal of gastroenterology · 2022Review
- SARS-CoV-2 Morbidity in the CNS and the Aged Brain Specific Vulnerability.International journal of molecular sciences · 2022Review
- Foe and friend in the COVID-19-associated acute kidney injury: an insight on intrarenal renin-angiotensin system.Acta biochimica et biophysica Sinica · 2022Review
- Multi-Data Integration Towards a Global Understanding of the Neurological Impact of Human Brain Severe Acute Respiratory Syndrome Coronavirus 2 Infection.Frontiers in integrative neuroscience · 2022Article
- Bimodal distribution of thyroid dysfunction triggered by COVID-19 Infection: An experience from a single endocrine center-a case series and literature review.Qatar medical journal · 2022Article
- Effects of COVID-19 and mRNA vaccines on human fertility.Human reproduction (Oxford, England) · 2021Article
- Impact of COVID-19 on the thyroid gland: an update.Reviews in endocrine & metabolic disorders · 2021Review
- A pancancer overview of FBN1, asprosin and its cognate receptor OR4M1 with detailed expression profiling in ovarian cancer.Oncology letters · 2021Article
- Ectopic Odorant Receptor Responding to Flavor Compounds: Versatile Roles in Health and Disease.Pharmaceutics · 2021Review
- Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19.The Australian and New Zealand journal of psychiatry · 2021Article
- Epigenomics in COVID-19; the link between DNA methylation, histone modifications and SARS-CoV-2 infection.Epigenomics · 2021Article
- COVID‑19 and SARS‑CoV‑2 host cell entry mediators: Expression profiling of TMRSS4 in health and disease.International journal of molecular medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV‑2) enters into human host cells via mechanisms facilitated mostly by angiotensin‑converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). New loss of smell (anosmia/hyposmia) is now recognized as a COVID‑19 related symptom, which may be caused by SARS‑CoV‑2 infection and damage of the olfactory receptor (OR) cells in the nasal neuro‑epithelium and/or central involvement of the olfactory bulb. ORs are also expressed peripherally (e.g., in tissues of the gastrointestinal and respiratory systems) and it is possible that their local functions could also be impaired by SARS‑CoV‑2 infection of these tissues. Using Gene Expression Profiling Interactive Analysis, The Cancer Genome Atlas, Genotype‑Tissue Expression, cBioPortal and Shiny Methylation Analysis Resource Tool, we highlight the expression of peripheral ORs in both healthy and malignant tissues, and describe their co‑expression with key mediators of SARS‑CoV‑2 infection, such as ACE2 and TMPRSS2, as well as cathepsin L (CTSL; another cellular protease mediating SARS‑CoV‑2 infection of host cells). A wide expression profile of peripheral ORs was noted, particularly in tissues such as the prostate, testis, thyroid, brain, liver, kidney and bladder, as well as tissues with known involvement in cardio‑metabolic disease (e.g., the adipose tissue, pancreas and heart). Among these, OR51E2, in particular, was significantly upregulated in prostate adenocarcinoma (PRAD) and co‑expressed primarily with TMPRSS2. Functional networks of this OR were further analysed using the GeneMANIA interactive tool, showing that OR51E2 interacts with a plethora of genes related to the prostate. Further in vitro and clinical studies are clearly required to elucidate the role of ORs, both at the olfactory level and the periphery, in the context of COVID‑19.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.