Observational studyBrain : a journal of neurology2020
Structural white matter connectometry of word production in aphasia: an observational study.
Observational study in Brain : a journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 69 citations in OpenAlex.
- Trial
- Post-stroke enriched auditory environment induces structural connectome plasticity: secondary analysis from a randomized controlled trial.Brain imaging and behavior · 2022Trial
- Scalp acupuncture coupled with speech-language therapy modulates the ventral-dorsal structural brain network in patients with post-stroke anomia: a randomized clinical and DTI neuroimaging trial.Chinese medicine · 2026Article
- Evaluating Unimodal and Multimodal Tracking Strategies for the Reconstruction of Language-related White Matter Tracts.Clinical neuroradiology · 2026Article
- Double dissociation between conduction aphasia and conduction agraphia supports a ventro-dorsal partition of the left arcuate fasciculus.Journal of neuropsychology · 2026Article
- Abnormalities in brain white matter structural networks associated with language function of post-stroke aphasia.Brain imaging and behavior · 2026Article
- Tractography-based correlation of diffusion anisotropy metrics in chronic post-stroke aphasia.BMC medical imaging · 2026Article
- Diffusion Tensor Imaging and Advanced Diffusion Imaging in Post-Stroke Aphasia Recovery.Tomography (Ann Arbor, Mich.) · 2026Review
- Semantic Memory, Traumatic Brain Injury, and the Iceberg Effect: What Deficits May Lie Below the Surface?American journal of speech-language pathology · 2025Review
- Neural pathways underlying the production of pitch and rhythm in aphasia.Annals of the New York Academy of Sciences · 2025Article
- Semantic and Phonological Abilities Inform Efficacy of Transcranial Magnetic Stimulation on Sustained Aphasia Treatment Outcomes.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Functional anatomy and topographical organization of the frontotemporal arcuate fasciculus.Communications biology · 2024Article
- The Relationship between White Matter Architecture and Language Lateralization in the Healthy Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Rational adaptation in word production: Strong conceptual ability reduces the effect of lexical impairments on verb retrieval in aphasia.Neuropsychologia · 2024Article
- Assessing Relative Linguistic Impairment With Model-Based Item Selection.Journal of speech, language, and hearing research : JSLHR · 2024Article
- The role of language-related functional brain regions and white matter tracts in network plasticity of post-stroke aphasia.Journal of neurology · 2024Review
- Choir singing is associated with enhanced structural connectivity across the adult lifespan.Human brain mapping · 2024Article
- Structural brain networks correlating with poststroke cognition.Human brain mapping · 2024Observational
- The volume and the distribution of premorbid white matter hyperintensities: Impact on post-stroke aphasia.Human brain mapping · 2024Article
- Sex differences in patterns of white matter neuroplasticity after balance training in young adults.Frontiers in human neuroscience · 2024Article
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
While current dual-steam neurocognitive models of language function have coalesced around the view that distinct neuroanatomical networks subserve semantic and phonological processing, respectively, the specific white matter components of these networks remain a matter of debate. To inform this debate, we investigated relationships between structural white matter connectivity and word production in a cross-sectional study of 42 participants with aphasia due to unilateral left hemisphere stroke. Specifically, we reconstructed a local connectome matrix for each participant from diffusion spectrum imaging data and regressed these matrices on indices of semantic and phonological ability derived from their responses to a picture-naming test and a computational model of word production. These connectometry analyses indicated that both dorsally located (arcuate fasciculus) and ventrally located (inferior frontal-occipital, uncinate, and middle longitudinal fasciculi) tracts were associated with semantic ability, while associations with phonological ability were more dorsally situated, including the arcuate and middle longitudinal fasciculi. Associations with limbic pathways including the posterior cingulum bundle and the fornix were also found. All analyses controlled for total lesion volume and all results showing positive associations obtained false discovery rates < 0.05. These results challenge dual-stream accounts that deny a role for the arcuate fasciculus in semantic processing, and for ventral-stream pathways in language production. They also illuminate limbic contributions to both semantic and phonological processing for word production.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.