Evidence map›Paper›PMID 32705091›Full record

ArticleMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention2019

Variational AutoEncoder For Regression: Application to Brain Aging Analysis.

Qingyu Zhao, Ehsan Adeli, Nicolas Honnorat, Tuo Leng, Kilian M Pohl

Abstract read
In one paragraph

Article in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Deep learning for optical tweezers.Nanophotonics (Berlin, Germany) · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Attentional Generative Multimodal Network for Neonatal Postoperative Pain Estimation.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2022
    Article
  15. Longitudinal self-supervised learning.Medical image analysis · 2021
    Article
  16. Review
  17. Deep Generative Analysis for Task-Based Functional MRI Experiments.Proceedings of machine learning research · 2021
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qingyu ZhaoStanford University, Stanford, CA, USA.
Ehsan AdeliStanford University, Stanford, CA, USA.
Nicolas HonnoratSRI International, Menlo Park, CA, USA.
Tuo LengStanford University, Stanford, CA, USA.
Kilian M PohlStanford University, Stanford, CA, USA.

Funding

Neuroimaging of Alcohol-Induced Neuroadaptation: Translation From Animals to HumansU01AA013521 · NIAAA · SRI INTERNATIONAL · PI PFEFFERBAUM, ADOLF, ZAHR, NATALIE M · 2001 to 2021
$15.2M
CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISMR01AA005965 · NIAAA · STANFORD UNIVERSITY · PI PFEFFERBAUM, ADOLF, ZAHR, NATALIE M · 1985 to 2025
$13.0M
NCANDA: Data Analysis Resource - Uploading Legacy Data to NDAU24AA021697 · NIAAA · STANFORD UNIVERSITY · PI Adolf Pfefferbaum, Kilian Maria Pohl · 2016 to 2026
$12.2M
Cerebellar Structure and Function in AlcoholismR37AA010723 · NIAAA · STANFORD UNIVERSITY · PI SULLIVAN, EDITH VIONI · 2010 to 2019
$5.4M
CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISMR37AA005965 · NIAAA · STANFORD UNIVERSITY · PI PFEFFERBAUM, ADOLF · 1996 to 2005
$4.4M
Translational Studies of Brain Circuitry Disrupted by AlcoholismK05AA017168 · NIAAA · STANFORD UNIVERSITY · PI SULLIVAN, EDITH VIONI · 2008 to 2017
$2.2M
Identifying Patterns of Cognitive, Motor, and Brain Structural Abnormalities Differentiating Alcohol Use Disorder with and without HIV Infection ComorbidityF32AA026762 · NIAAA · STANFORD UNIVERSITY · PI ADELI, EHSAN · 2018 to 2019
$86k
NIAAA NIH HHS F32 AA026762NIAAA NIH HHS K05 AA017168NIAAA NIH HHS R01 AA005965NIAAA NIH HHS R37 AA005965NIAAA NIH HHS R37 AA010723NIAAA NIH HHS U01 AA013521NIAAA NIH HHS U24 AA021697
6 · The paper itself

Abstract

While unsupervised variational autoencoders (VAE) have become a powerful tool in neuroimage analysis, their application to supervised learning is under-explored. We aim to close this gap by proposing a unified probabilistic model for learning the latent space of imaging data and performing supervised regression. Based on recent advances in learning disentangled representations, the novel generative process explicitly models the conditional distribution of latent representations with respect to the regression target variable. Performing a variational inference procedure on this model leads to joint regularization between the VAE and a neural-network regressor. In predicting the age of 245 subjects from their structural Magnetic Resonance (MR) images, our model is more accurate than state-of-the-art methods when applied to either region-of-interest (ROI) measurements or raw 3D volume images. More importantly, unlike simple feed-forward neural-networks, disentanglement of age in latent representations allows for intuitive interpretation of the structural developmental patterns of the human brain.

Identifiers

PMID32705091
PMCPMC7377006

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.