Evidence map›Paper›PMID 32704851›Full record

ArticleTranslational animal science2019

Moderate nutrient restriction of beef heifers alters expression of genes associated with tissue metabolism, accretion, and function in fetal liver, muscle, and cerebrum by day 50 of gestation.

Matthew S Crouse, Joel S Caton, Robert A Cushman, Kyle J McLean, Carl R Dahlen, Pawel P Borowicz, Lawrence P Reynolds, Alison K Ward

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational animal science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
8.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Matthew S CrouseDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND.
Joel S CatonDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND.
Robert A CushmanUSDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE.
Kyle J McLeanDepartment of Animal Science, University of Tennessee, Knoxville, TN.
Carl R DahlenDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND.
Pawel P BorowiczDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND.
Lawrence P ReynoldsDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND.
Alison K WardDepartment of Animal Sciences, Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND.
North Dakota State University · USRoman L. Hruska U.S. Meat Animal Research Center · USUniversity of Tennessee at Knoxville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We hypothesized that a moderate maternal nutrient restriction during the first 50 d of gestation in beef heifers would affect transcript abundance of genes associated with tissue metabolism, accretion, and function in fetal liver, muscle, and cerebrum. Angus-cross heifers were estrus synchronized and assigned at breeding to one of two dietary treatments (CON- 100% of nutrient requirements to gain 0.45 kg/d; RES- 60% of CON). At day 50 of gestation, 14 heifers were ovariohysterectomized, and fetal liver, muscle, and cerebrum were collected. Transcriptome analysis via RNA-seq was conducted on the Illumina HiSeq 2500 platform using 50-bp paired-end reads at a depth of 2 × 10.4M reads/sample. Bioinformatic analysis was performed using the Tuxedo Suite and ontological analysis with DAVID 6.8. For fetal liver, muscle, and cerebrum, a total of 548, 317, and 151 genes, respectively (

Indexed as

developmental programmingfetusnutritionRNA-Seq

Identifiers

PMID32704851
PMCPMC7200894
OpenAlexW2917612233

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.