ArticleActa pharmaceutica Sinica. B2012
AMPK in myocardial infarction and diabetes: the yin/yang effect.
Article in Acta pharmaceutica Sinica. B, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Hypoxia, ROS, and HIF Signaling in I/R Injury: Implications and Future Prospects.Antioxidants (Basel, Switzerland) · 2026Review
- PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.Journal of pharmaceutical analysis · 2023Article
- Toll-Like Receptor 4 (TLR4) and AMPK Relevance in Cardiovascular Disease.Advanced pharmaceutical bulletin · 2023Review
- The Role of Mitochondrial Enzymes, Succinate-Coupled Signaling Pathways and Mitochondrial Ultrastructure in the Formation of Urgent Adaptation to Acute Hypoxia in the Myocardium.International journal of molecular sciences · 2022Article
- Akt Inhibition as Preconditioning Treatment to Protect Kidney Cells against Anoxia.International journal of molecular sciences · 2021Article
- Energy metabolism disorders and potential therapeutic drugs in heart failure.Acta pharmaceutica Sinica. B · 2021Review
- Similarities between the Yin/Yang Doctrine and Hormesis in Toxicology and Pharmacology.Trends in pharmacological sciences · 2020Review
- The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity.Cardiovascular drugs and therapy · 2020Review
- Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-κB pathway.Metabolism: clinical and experimental · 2018Article
- The structure-activity relationship of ginsenosides on hypoxia-reoxygenation induced apoptosis of cardiomyocytes.Biochemical and biophysical research communications · 2017Article
- Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- The Modulation of Cardiac Contractile Function by the Pharmacological and Toxicological Effects of Urocortin2.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Metabolic shifts during aging and pathology.Comprehensive Physiology · 2015Review
- Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Antithrombin up-regulates AMP-activated protein kinase signalling during myocardial ischaemia/reperfusion injury.Thrombosis and haemostasis · 2015Article
- AMPK Activators as a Drug for Diabetes, Cancer and Cardiovascular Disease.Pharmaceutical regulatory affairs : open access · 2014Article
- Alpha1 catalytic subunit of AMPK modulates contractile function of cardiomyocytes through phosphorylation of troponin I.Life sciences · 2014Article
- Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway.Mediators of inflammation · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
There has been considerable progress in our understanding of cardiac cell metabolism in health and disease, yet important gaps remain in basic knowledge and its translation to clinical care. AMP-activated protein kinase (AMPK) functions either to conserve ATP or to promote alternative methods of ATP generation. Since the discovery of AMPK more than three decades ago and demonstration of its expression in the heart, interest has grown exponentially in this major fuel gauge as a modulator of the cellular response to ischemia. Such pathway may potentially explain the strong association between metabolic syndrome and ischemic heart disease. Still missing from our most recent cardiology textbooks, this article aims to summarize our understanding so far of the role of AMPK in coordinating the cellular response to ischemic stress and reperfusion injury in the heart. We aim to provide a focused update on the pharmacological agents activating AMPK for treatment of diabetes that show potential cardioprotective effects. Our hope is to stimulate future researchers to the potential benefits of harnessing the AMPK signaling pathway, or better one of its novel downstream targets for the treatment of myocardial ischemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.