Evidence map›Paper›PMID 32704466›Full record

ArticleCurrent clinical microbiology reports2020

Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation.

Alexis Bouin, Bert L Semler

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current clinical microbiology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Opposing fates: a bipolar cellular model for FMDV replication shaped byFrontiers in cellular and infection microbiology · 2025
    Article
  2. PRSC chemical biology · 2023
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexis BouinDepartment of Microbiology & Molecular Genetics and Center for Virus Research, School of Medicine, University of California, Med Sci Bldg, Room B237, Irvine, CA 92697-4025, USA.
Bert L SemlerDepartment of Microbiology & Molecular Genetics and Center for Virus Research, School of Medicine, University of California, Med Sci Bldg, Room B237, Irvine, CA 92697-4025, USA.
University of California, Irvine · US

Funding

Impact of host protein dynamics on picornavirus RNA 5’ noncoding region functionsR01AI026765 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SEMLER, BERT L · 1988 to 2019
$5.9M
POLIOVIRUS GENE FUNCTION AND REGULATIONR01AI022693 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SEMLER, BERT L · 1985 to 2015
$4.6M
Functions of 5' NCRs of picornavirus and cellular mRNAsR56AI026765 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SEMLER, BERT L · 2008 to 2008
$369k
NIAID NIH HHS R01 AI022693NIAID NIH HHS R01 AI026765NIAID NIH HHS R56 AI026765
6 · The paper itself

Abstract

purpose of reviewTo highlight recent findings on how picornavirus infections of the airways and cardiac tissues impact cellular inflammation and remodeling events. RECENT

findingsRecent published work has revealed that although many picornavirus infections appear to be initially asymptomatic, there are significant disease sequelae that result from chronic or persistent infections and the long-term, pathogenic effects on host tissues. SUMMARY: Because many acute picornavirus infections are asymptomatic, it is difficult to diagnose these pathologies at the early stages of disease. As a result, we must rely on preventative measures (i.e., vaccination) or discover novel treatments to reverse tissue damage and remodeling in affected individuals. Both of these strategies will require a comprehensive knowledge of virus-and cell-specific replication determinants and how these processes induce pathogenic effects in infected cells and tissues.

Indexed as

AsthmaCoxsackievirusCystic fibrosisInflammationMyocarditisPicornavirusRemodelingRhinovirus

Identifiers

PMID32704466
PMCPMC7377643
OpenAlexW3016788503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.