Evidence map›Paper›PMID 32704410›Full record

ArticleInternational journal of MCH and AIDS2020

Detectable HIV-RNA Viral Load Among HIV-Infected Pregnant Women on Treatment in Northern Uganda.

Agnes Napyo, James K Tumwine, David Mukunya, Josephine Tumuhamye, Anna Agnes Ojok Arach, Grace Ndeezi, Paul Waako, Thorkild Tylleskär

Open access · goldAbstract read
In one paragraph

Article in International journal of MCH and AIDS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.0field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Agnes NapyoDepartment of Public Health, Faculty of Health Sciences, Busitema University, 236 Tororo, Uganda.
James K TumwineDepartment of Pediatrics and Child Health, Makerere University, 7062 Kampala, Uganda.
David MukunyaCentre for International Health, University of Bergen, 7804 Bergen, Norway.
Josephine TumuhamyeCentre for International Health, University of Bergen, 7804 Bergen, Norway.
Anna Agnes Ojok ArachDepartment of Pediatrics and Child Health, Makerere University, 7062 Kampala, Uganda.
Grace NdeeziDepartment of Pediatrics and Child Health, Makerere University, 7062 Kampala, Uganda.
Paul WaakoDepartment of Pharmacology, Faculty of Health Sciences, Busitema University, 236 Tororo, Uganda.
Thorkild TylleskärCentre for International Health, University of Bergen, 7804 Bergen, Norway.
University of Bergen · NOBusitema University · UGMakerere University · UGLira Hospital · UG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND /

objectivesDetectable HIV viral load among HIV-infected pregnant women remains a public health threat. We aimed to determine factors associated with detectable viral load among HIV-infected pregnant women in Lira, Northern Uganda.

methodsWe conducted a cross-sectional survey among 420 HIV-infected pregnant women attending Lira Regional Referral Hospital using a structured questionnaire and combined it with viral load tests from Uganda National Health Laboratories. We conducted multivariable logistic regression while adjusting for confounders to determine the factors associated with detectable viral load and we report adjusted odds ratios and proportion of women with viral load less than 50 copies/ml and above 1000 copies, respectively.

resultsThe prevalence of detectable viral load (>50 copies/ml) was 30.7% (95%CI: 26.3% - 35.4%) and >1000 copies/ml was 8.1% (95% CI: 5.7% - 11.1%). Factors associated with detectable viral load were not belonging to the CONCLUSIONS AND GLOBAL HEALTH IMPLICATIONS: HIV-infected pregnant women likely to have detectable viral load included those taking a protease inhibitor-based regimen and those who were not natives of Lira. We recommend intensified clinical and psychosocial monitoring for medication compliance among HIV-infected pregnant women that are likely to have a detectable viral load to significantly lower the risk of vertical transmission of HIV in Lira specifically those taking a protease inhibitor-based regimen and those who are non-natives to the study setting. Much as the third 90% of the global UNAIDS 90-90-90 target has been achieved, the national implementation of PMTCT guidelines should be tailored to its contextual needs.

Indexed as

Antiretroviral therapyHIVPMTCTPregnancyPregnant womenUgandaViral loadViral suppressionWomen

Identifiers

PMID32704410
PMCPMC7370273
OpenAlexW3039771847

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.