ArticleEFSA journal. European Food Safety Authority2017
Risk for the development of Antimicrobial Resistance (AMR) due to feeding of calves with milk containing residues of antibiotics.
Article in EFSA journal. European Food Safety Authority, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 82 citations in OpenAlex.
- Impacts of feeding preweaned calves milk containing drug residues on the functional profile of the fecal microbiota.Scientific reports · 2018Trial
- Nasopharyngeal microbiome and resistome profiles in dairy calves fed milk replacer with low-level β-lactams.JDS communications · 2026Article
- Extended-spectrum beta-lactamases from French veal calves: WGS-based data will help build targeted AMR mitigation strategies.Microbiology spectrum · 2026Article
- Epidemiology of Antimicrobial Residues and Phenotypic Resistance of Bacterial Isolates from Waste Milk on California Dairies.Microorganisms · 2026Article
- Evaluation of ß-lactamase-induced inactivation of penicillin G and cefoperazone in spiked ultra-high temperature and raw unpasteurized milk.Frontiers in veterinary science · 2026Article
- Antibiotic Residues in Milk as a Consequence of Mastitis Treatment: Balancing Animal Welfare and One Health Risks.Veterinary sciences · 2025Review
- Changes in fecal microbiota after therapeutic exposure to amoxicillin-clavulanic acid in veal calves receiving multiple antibiotics.Microbiology spectrum · 2025Article
- Exploring colostrum microbiota and its influence on early calf gut microbiota development using full-length 16S rRNA gene metabarcoding.Scientific reports · 2025Article
- Analysis of pathogenic bacteria and antimicrobial residues in bovine waste milk on dairy farms in southern Chile.Frontiers in veterinary science · 2025Article
- Dairy Cattle and the Iconic Autochthonous Cattle in Northern Portugal Are Reservoirs of Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Mitigating antibiotics misuse in dairy farming systems and milk value chain market: Insights into practices, factors, and farmers education in Nyabihu district, Rwanda.One health (Amsterdam, Netherlands) · 2024Article
- Assessing antimicrobial resistance in pasture-based dairy farms: a 15-month surveillance study in New Zealand.Applied and environmental microbiology · 2024Article
- Efficacy of Copper Ion Treatment on Bacteria and Antibiotic Residues Contained in Bovine Waste Milk.Antibiotics (Basel, Switzerland) · 2024Article
- When the solution becomes the problem: a review on antimicrobial resistance in dairy cattle.Future microbiology · 2024Review
- Surveillance of Antimicrobial Resistance ofAnimals : an open access journal from MDPI · 2024Article
- Antimicrobial consumption and resistance in bacteria from humans and food-producing animals: Fourth joint inter-agency report on integrated analysis of antimicrobial agent consumption and occurrence of antimicrobial resistance in bacteria from humans and food-producing animals in the EU/EEA JIACRA IV - 2019-2021.EFSA journal. European Food Safety Authority · 2024Article
- Molecular Epidemiology and Antimicrobial Resistance of Extended-SpectrumVeterinary medicine international · 2024Article
- Clinical Application of Platelet Concentrates in Bovine Practice: A Systematic Review.Veterinary sciences · 2023Review
- Exploring Antimicrobial Resistance Profiles ofMicroorganisms · 2023Article
- Heat Inactivation of Methicillin-ResistantAnimals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
32 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
EFSA was requested to: 1) assess the risk for the development of antimicrobial resistance (AMR) due to feeding on farm of calves with colostrum potentially containing residues of antibiotics; 2) assess the risk for the development of AMR due to feeding on farm of calves with milk of cows treated during lactation with an antibiotic and milked during the withdrawal period, and 3) propose possible options to mitigate the risk for the development of AMR derived from such practices. Treatment of dairy cows during the dry period and during lactation is common in the EU Member States. Penicillins, alone or in combination with aminoglycosides, and cephalosporins are most commonly used. Residue levels of antimicrobials decrease with the length of the dry period. When the interval from the start of the drying-off treatment until calving is as long as or longer than the minimum specified in the Summary of Product Characteristics of the antimicrobial, faecal shedding of antimicrobial-resistant bacteria will not increase when calves are fed colostrum from treated cows. Milk from cows receiving antimicrobial treatment during lactation contains substantial residues during the treatment and withdrawal period. Consumption of such milk will lead to increased faecal shedding of antimicrobial-resistant bacteria by calves. A range of possible options exist for restricting the feeding of such milk to calves, which could be targeting the highest priority critically important antimicrobials. β-Lactamases can reduce the concentration of β-lactams which are the most frequently used antimicrobials in milking cows. Options to mitigate the presence of resistant bacteria in raw milk or colostrum are mainly based on thermal inactivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.