Evidence map›Paper›PMID 32704167›Full record

Trial reportScientific reports2020

Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms.

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki and 8 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Neuro-environmental interactions: a time sensitive matter.Frontiers in computational neuroscience · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

Hikaru TakeuchiDivision of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, 980-8575, Japan. takehi@idac.tohoku.ac.jp.
Yasuyuki TakiDivision of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, 980-8575, Japan.
Rui NouchiCreative Interdisciplinary Research Division, Frontier Research Institute for Interdisciplinary Science, Tohoku University, Sendai, Japan.
Ryoichi YokoyamaSchool of Medicine, Kobe University, Kobe, Japan.
Yuka KotozakiDivision of Clinical Research, Medical-Industry Translational Research Center, Fukushima Medical University School of Medicine, Fukushima, Japan.
Seishu NakagawaDepartment of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Atsushi SekiguchiDivision of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Kunio IizukaDepartment of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Sugiko HanawaDepartment of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Tsuyoshi ArakiAdvantage Risk Management Co., Ltd., Tokyo, Japan.
Carlos Makoto MiyauchiDepartment of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Kohei SakakiDepartment of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Takayuki NozawaResearch Center for the Earth Inclusive Sensing Empathizing with Silent Voices, Tokyo Institute of Technology, Tokyo, Japan.
Shigeyuki IkedaDepartment of Ubiquitous Sensing, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Susum YokotaDivision for Experimental Natural Science, Faculty of Arts and Science, Kyushu University, Fukuoka, Japan.
Daniele MagistroDepartment of Sport Science, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Yuko SassaDivision of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, 980-8575, Japan.
Ryuta KawashimaDivision of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai, 980-8575, Japan.
Tohoku University · JPTohoku Medical Megabank Organization · JPFukushima Medical University · JPKobe University · JPKyushu University · JPNottingham Trent University · GBTohoku Medical and Pharmaceutical University · JPTokyo Institute of Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc is a biologically essential element and involved in a wide range of cellular processes. Here, we investigated the associations of zinc levels in hair with brain activity during the n-back working memory task using functional magnetic resonance imaging, fractional anisotropy (FA) of diffusion tensor imaging, and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that greater hair zinc levels were associated with lower brain activity during working memory in extensive areas in the default mode network (i.e., greater task-induced deactivation) as well as greater FA in white matter areas near the hippocampus and posterior limbs of the internal capsule. These findings advance previous non-neuroimaging findings of zinc's associations with excitability, excitability-associated disorders, and myelination.

Indexed as

BrainDiffusion Tensor ImagingHairMemory, Short-TermAdolescentAdultFemaleHumansMaleYoung AdultZincZinc

Identifiers

PMID32704167
PMCPMC7378227
OpenAlexW3045070093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.