ArticleScientific reports2020
Probing driving forces for binding between nanoparticles and amino acids by saturation-transfer difference NMR.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Silver and polystyrene nanoparticles activate oestrogen signalling via cytoplasmic oestrogen receptor.Scientific reports · 2025Article
- Tutorial: Saturation Transfer Difference NMR for Studying Small Molecules Interacting With Nanoparticles.Magnetic resonance in chemistry : MRC · 2025Article
- ZIF-8 Microswimmers Self-Fast Dynamic Destruction in Microliter Volumes of Cerebrospinal Fluid Samples: Toward a Selective Assessment of Amyloidosis.Analytical chemistry · 2025Article
- Self-Disassembling Macroporous Metal-Organic Framework-Based Micromotors with Magnetically Controlled Motion for Sequential Drug Release.Small methods · 2025Article
- Oral Exposure to Nylon-11 and Polystyrene Nanoplastics During Early-Life in Rats.Nanomaterials (Basel, Switzerland) · 2025Article
- Insights into nanoparticle surface bonding and coating architecture via multinuclear NMR.Academia nano : science, materials, technology · 2025Article
- Numerical Study towards In Vivo Tracking of Micro-/Nanoplastic Based on X-ray Fluorescence Imaging.Biomedicines · 2024Article
- Protein Binding Leads to Reduced Stability and Solvated Disorder in the Polystyrene Nanoparticle Corona.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Article
- Binding Between Antibiotics and Polystyrene Nanoparticles Examined by NMR.ACS environmental Au · 2023Article
- Solution NMR methods for structural and thermodynamic investigation of nanoparticle adsorption equilibria.Nanoscale advances · 2022Review
- Analytical Methods for Characterization of Nanomaterial Surfaces.Analytical chemistry · 2021Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
As nanotechnology becomes increasingly used in biomedicine, it is important to have techniques by which to examine the structure and dynamics of biologically-relevant molecules on the surface of engineered nanoparticles. Previous work has shown that Saturation-Transfer Difference (STD)-NMR can be used to explore the interaction between small molecules, including amino acids, and the surface of polystyrene nanoparticles. Here we use STD-NMR to further explore the different driving forces that are responsible for these interactions. Electrostatic effects are probed by using zwitterionic polystyrene beads and performing STD-NMR experiments at high, low, and neutral pH, as well as by varying the salt concentration and observing the effect on the STD buildup curve. The influence of dispersion interactions on ligand-nanoparticle binding is also explored, by establishing a structure-activity relationship for binding using a series of unnatural amino acids with different lengths of hydrophobic side chains. These results will be useful for predicting which residues in a peptide are responsible for binding and for understanding the driving forces for binding between peptides and nanoparticles in future studies.
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