ArticleScientific reports2020
The role of the immune system and the biomarker CD3 + CD4 + CD45RA-CD62L- in the pathophysiology of migraine.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Regulatory T cell levels in migraine: A systematic review and meta-analysis.The journal of headache and pain · 2026Pooled it
- Migraine immune cell gene targets and their relationship to psychiatric disorders.The journal of headache and pain · 2026Article
- Cellular and molecular characterisation of the peripheral immune environment in migraine.Pain reports · 2025Article
- Patterns of Past COVID-19 and EBV Infection in Primary Headache Disorders: A Population Study.Brain and behavior · 2025Article
- Revisiting Migraine Pathophysiology: from Neurons To Immune Cells Through Lens of Immune Regulatory Pathways.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Review
- Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status?The journal of headache and pain · 2025Article
- Exploring the CD3/CD56/TNF-α/Caspase3 pathway in pyrethroid-induced immune dysregulation: curcumin-loaded chitosan nanoparticle intervention.Frontiers in pharmacology · 2025Article
- A Review of the Biochemical Diagnostic Biomarkers in Migraine: New Perspectives in Diagnostics.Pain research & management · 2025Review
- Association between monocyte-to-HDL ratio and Fazekas-scaled white matter hyperintensities in migraine patients: a cross-sectional MRI-based study.Frontiers in neurology · 2025Article
- Understanding the Biological Relationship between Migraine and Depression.Biomolecules · 2024Review
- Glia Signaling and Brain Microenvironment in Migraine.Molecular neurobiology · 2023Review
- Common Clinical and Molecular Pathways between Migraine and Sarcoidosis.International journal of molecular sciences · 2023Review
- Metabolic profile changes in serum of migraine patients detected usingThe journal of headache and pain · 2021Article
- Migraine with Brainstem Aura Accompanied by Disorders of Consciousness.Journal of pain research · 2021Review
- Headache Medicine Grand Challenge: Headache: A New Frontier, A New Challenge.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- A Preliminary Meta-analysis of Regulatory T-cell Reduction in Patients With Migraine.Basic and clinical neuroscienceReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the immune system as an integral component of the inflammatory response in the pathophysiology of migraine remains unclear. The aim of this study was to evaluate the differences in immune system parameters (acquired immunity parameters) in patients with episodic migraine (EM) and in healthy controls. In EM patients, we aimed to determine whether the changes found in peripheral blood parameters were related to migraine severity according to the standardised MIDAS and HIT-6 tests. Forty-nine patients with EM and 50 healthy controls were included in this study. The authors compared different lymphocyte parameters obtained by multicolor flow cytometry in the EM and control groups by performing statistical tests. The relationship between the changes in peripheral blood parameters and migraine severity in EM patients was investigated using correlation and regression analysis. EM patients showed higher values than healthy controls, especially in nine parameters: relative count of lymphocytes, relative and absolute counts of CD3 T cells, relative and absolute counts of CD8 suppressor cytotoxic T cells, relative and absolute counts of CD4 + T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.