ArticleScientific reports2020
Live imaging and functional changes of the inner ear in an animal model of Meniere's disease.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Systems Network Integration of Transcriptomic, Proteomic, and Bioinformatic Analyses Reveals the Mechanism of XuanYunNing Tablets in Meniere's Disease via JAK-STAT Pathway Modulation.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Intracochlear Imaging Using IVUS and OFDI: A Cadaveric Feasibility Study.Laryngoscope investigative otolaryngology · 2025Article
- Ménière's disease and vestibular migraine: a narrative review of pathogenetic insights, diagnostic evolution, and clinical management advances.Frontiers in neurology · 2025Review
- Prognosis of asymptomatic endolymphatic hydrops in healthy volunteers: A five-year cohort study.Laryngoscope investigative otolaryngology · 2024Article
- Factors associated with spontaneous nystagmus changes in acute Ménière's disease.Journal of neurology · 2024Observational
- Three-dimensional mouse cochlea imaging based on the modified Sca/eS using confocal microscopy.Anatomical science international · 2023Article
- The role of the stria vascularis in neglected otologic disease.Hearing research · 2023Review
- Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease.International journal of molecular sciences · 2022Review
- Endolymphatic Sac Drainage Surgery and Plasma Stress Hormone Vasopressin Levels in Meniere's Disease.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The symptoms of Meniere's disease (MD) are generally considered to be related to endolymphatic hydrops (EH). There are many recent reports supporting the possibility that vasopressin (VP) is closely linked to the formation of EH in Meniere's disease. Based on this, we developed a clinically relevant animal model of Meniere's disease in which a VP type 2 receptor agonist was administered after electrocauterization of the endolymphatic sac. We report live imaging of the internal structure, and functional changes of the inner ear after electrocauterization of the endolymphatic sac and administration of a VP type 2 receptor agonist. In this model, the development of EH was visualized in vivo using optical coherence tomography, there was no rupture of Reissner's membrane, and low-tone hearing loss and vertiginous attacks were observed. This study suggested that acute attacks are caused by the abrupt development of EH. This is the first report of live imaging of the development of EH induced by the administration of a VP type 2 receptor agonist.
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