ArticleScientific reports2020
Impact of admission serum ionized calcium levels on risk of acute kidney injury in hospitalized patients.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 27 citations in OpenAlex.
- DCBM-Tri: a dual-channel bilinear mapping triplet model for early recognition of acute kidney injury in imbalanced cohorts.Scientific reports · 2026Article
- Discovery of postoperative clinical states linked to cardiac surgery-associated acute kidney injury.BioData mining · 2026Article
- Severity, etiology and outcomes of ionized hypocalcemia in azotemic cats and dogs.Frontiers in veterinary science · 2026Article
- Diagnostic PANoptosis-related genes in acute kidney injury: bioinformatics, machine learning, and validation.Annals of medicine · 2025Article
- Machine learning-based risk prediction model development for acute kidney injury in type 2 myocardial infarction patients.Scientific reports · 2025Article
- Clinical Profiles and Mortality-Associated Risk Factors in Patients with Acute Kidney Injury from Atlixco, Puebla, Mexico.Diagnostics (Basel, Switzerland) · 2025Article
- Arterial Stiffness and Acute Kidney Injury in the Atherosclerosis Risk in Communities (ARIC) Study.Kidney medicine · 2025Article
- Article
- Establishment and validation of a prediction model for acute kidney injury in moderate severe and severe acute pancreatitis patients.European journal of medical research · 2025Article
- Clinicopathologic predictors of renal response and survival in newly diagnosed multiple myeloma with renal injury: a retrospective study.Clinical and experimental medicine · 2025Article
- Excessive Ingestion of Almond Milk Causes Severe Hypercalcemia and Acute Kidney Injury in a Patient With Chronic Kidney Disease.Ochsner journal · 2025Article
- Analysis of serum calcium change trajectories and prognostic factors in patients with acute type A aortic dissection.BMC surgery · 2023Article
- Giant Mandibular Ameloblastoma with Rare Hypercalcemia: A Case Report and Literature Review.Medicina (Kaunas, Lithuania) · 2023Review
- Exploiting Machine Learning Technologies to Study the Compound Effects of Serum Creatinine and Electrolytes on the Risk of Acute Kidney Injury in Intensive Care Units.Diagnostics (Basel, Switzerland) · 2023Article
- Stratification of Acute Kidney Injury Risk, Disease Severity, and Outcomes by Electrolyte Disturbances.Journal of clinical medicine research · 2023Review
- Admission electrolyte and osmotic pressure levels are associated with the incidence of contrast-associated acute kidney injury.Scientific reports · 2022Article
- Unsupervised clustering reveals phenotypes of AKI in ICU COVID-19 patients.Frontiers in medicine · 2022Article
- Clinically Distinct Subtypes of Acute Kidney Injury on Hospital Admission Identified by Machine Learning Consensus Clustering.Medical sciences (Basel, Switzerland) · 2021Article
- Prediction models for acute kidney injury in critically ill patients: a protocol for systematic review and critical appraisal.BMJ open · 2021Article
- Hospital-Acquired Serum Ionized Calcium Derangements and Their Associations with In-Hospital Mortality.Medicines (Basel, Switzerland) · 2020Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate the risk of acute kidney injury (AKI) in hospitalized patients based on admission serum ionized calcium levels. This is a cohort study of all hospitalized adult patients, from January 2009 to December 2013 at a tertiary referral hospital, who had available serum ionized calcium at the time of admission. We excluded patients who had end-stage kidney disease or AKI at admission. We stratified admission serum ionized calcium into 6 groups; ≤ 4.39, 4.40-4.59, 4.60-4.79, 4.80-4.99, 5.00-5.19, and ≥ 5.20 mg/dL. We used serum creatinine criterion of KDIGO definition for diagnosis of AKI. We performed logistic regression analysis to assess the risk of in-hospital AKI occurrence based on admission serum ionized calcium, using serum ionized calcium of 5.00-5.19 mg/dL as the reference group. We studied a total of 25,844 hospitalized patients. Of these, 3,294 (12.7%) developed AKI in hospital, and 622 (2.4%) had AKI stage 2 or 3. We observed a U-shaped association between admission serum ionized calcium and in-hospital AKI, with nadir in-hospital AKI was in serum ionized calcium of 5.00-5.19 mg/dL. After adjustment for confounders, low serum ionized calcium of 4.40-4.59, ≤ 4.39 mg/dL and elevated serum ionized calcium ≥ 5.20 mg/dL were associated with increased risk of AKI with odds ratio of 1.33 (95% CI 1.14-1.56), 1.45 (95% CI 1.21-1.74), and 1.26 (95% CI 1.04-1.54), respectively. Both hypocalcemia, and hypercalcemia at the time of admission were associated with an increased risk of hospital-acquired AKI.
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