Evidence map›Paper›PMID 32704020›Full record

ArticleScientific reports2020

Antibacterial and antifungal activity of crude and freeze-dried bacteriocin-like inhibitory substance produced by Pediococcus pentosaceus.

Pamela Oliveira de Souza de Azevedo, Carlos Miguel Nóbrega Mendonça, Ana Carolina Ramos Moreno, Antonio Vinicius Iank Bueno, Sonia Regina Yokomizo de Almeida, Liane Seibert, Attilio Converti, Ii-Sei Watanabe, Martin Gierus, Ricardo Pinheiro de Souza Oliveira

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. The therapeutic potential ofFrontiers in microbiology · 2026
    Review
  2. Complete genome sequence ofMicrobiology resource announcements · 2025
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  3. Comparative Analyses ofMicroorganisms · 2025
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  10. Influence ofAnimals : an open access journal from MDPI · 2024
    Article
  11. Draft genome sequencing ofMicrobiology resource announcements · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Pan-genomic and comparative analysis ofComputational and structural biotechnology journal · 2022
    Article
  17. Review
  18. Article
  19. Frontiers in microbiology · 2021
    Review
  20. Frontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pamela Oliveira de Souza de AzevedoDepartment of Biochemical and Pharmaceutical Technology, University of São Paulo, São Paulo, SP, Brazil.
Carlos Miguel Nóbrega MendonçaDepartment of Biochemical and Pharmaceutical Technology, University of São Paulo, São Paulo, SP, Brazil.
Ana Carolina Ramos MorenoDepartment of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, SP, Brazil.
Antonio Vinicius Iank BuenoDepartment of Zootechnics, University of Maringá, Maringá, PR, Brazil.
Sonia Regina Yokomizo de AlmeidaDepartment of Anatomy, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
Liane SeibertDepartment of Animal Science, Laboratory of Ecology and Natural Grassland, Federal University of Santa Maria, Santa Maria, RS, Brazil.
Attilio ConvertiDepartment of Civil, Chemical and Environmental Engineering, Pole of Chemical Engineering, University of Genoa, Via Opera 15, 16145, Genoa, Italy.
Ii-Sei WatanabeDepartment of Anatomy, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
Martin GierusDepartment of Agrobiotechnology, Institute of Animal Nutrition, Livestock Products, and Nutrition Physiology (TTE), IFA-Tulln, University of Natural Resources and Life Sciences (BOKU), Vienna, Austria.
Ricardo Pinheiro de Souza OliveiraDepartment of Biochemical and Pharmaceutical Technology, University of São Paulo, São Paulo, SP, Brazil. rpsolive@usp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediococcus pentosaceus LBM 18 has shown potential as producer of an antibacterial and antifungal bacteriocin-like inhibitory substance (BLIS). BLIS inhibited the growth of spoilage bacteria belonging to Lactobacillus, Enterococcus and Listeria genera with higher activity than Nisaplin used as control. It gave rise to inhibition halos with diameters from 9.70 to 20.00 mm, with Lactobacillus sakei being the most sensitive strain (13.50-20.00 mm). It also effectively suppressed the growth of fungi isolated from corn grain silage for up to 25 days and impaired morphology of colonies by likely affecting fungal membranes. These results point out that P. pentosaceus BLIS may be used as a new promising alternative to conventional antibacterial and antifungal substances, with potential applications in agriculture and food industry as a natural bio-controlling agent. Moreover, cytotoxicity and cell death induction tests demonstrated cytotoxicity and toxicity of BLIS to human colon adenocarcinoma Caco-2cells but not to peripheral blood mononuclear cells, with suggests possible applications of BLIS also in medical-pharmaceutical applications.

Indexed as

Anti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsBacteriocinsBiological ProductsCell SurvivalDose-Response Relationship, DrugHumansLeukocytes, MononuclearMicrobial Sensitivity TestsPediococcus pentosaceusSpectrum AnalysisAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsBacteriocinsBiological Products

Identifiers

PMID32704020
PMCPMC7378238

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.