Evidence map›Paper›PMID 32703881›Full record

ArticleScience (New York, N.Y.)2020

Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division.

Evgeny Zatulovskiy, Shuyuan Zhang, Daniel F Berenson, Benjamin R Topacio, Jan M Skotheim

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 177 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mitotic Cdc42 waves encode PI(3,4)PScience advances · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Chromatin association promotes UBR5-mediated degradation of Rb.bioRxiv : the preprint server for biology · 2026
    Article
  12. Review
  13. Article
  14. Cell size modulates ferroptosis susceptibility.bioRxiv : the preprint server for biology · 2026
    Article
  15. Stress-dependent growth in breast cancer arises from a mechano-osmotic coupling and cell-sizing checkpoint.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Evgeny ZatulovskiyDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-7847-5829
Shuyuan Zhang *Department of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-6220-5998
Daniel F Berenson *Department of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-6396-6935
Benjamin R TopacioDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-2587-018X
Jan M SkotheimDepartment of Biology, Stanford University, Stanford, CA 94305, USA. skotheim@stanford.edu.ORCID 0000-0001-8420-6820
Stanford University · US

Funding

Determining how cell growth triggers cell divisionR35GM134858 · NIGMS · STANFORD UNIVERSITY · PI Jan M Skotheim · 2020 to 2026
$4.1M
Determining the molecular mechanism of cell size controlR01GM115479 · NIGMS · STANFORD UNIVERSITY · PI SKOTHEIM, JAN M · 2016 to 2019
$1.6M
Four Laser, 18 Color Cell Sorter in the SSFFS10RR025518 · NCRR · STANFORD UNIVERSITY · PI HERZENBERG, LEONARD A · 2009 to 2009
$500k
BD Canto II RUO CytometerS10RR027431 · NCRR · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2010 to 2010
$236k
Howard Hughes Medical InstituteNCRR NIH HHS S10 RR025518NCRR NIH HHS S10 RR027431NIGMS NIH HHS R01 GM115479NIGMS NIH HHS R35 GM134858
6 · The paper itself

Abstract

Cell size is fundamental to cell physiology. For example, cell size determines the spatial scale of organelles and intracellular transport and thereby affects biosynthesis. Although some genes that affect mammalian cell size have been identified, the molecular mechanisms through which cell growth drives cell division have remained elusive. We show that cell growth during the G

Indexed as

Cell Cycle CheckpointsCell DivisionCell ProliferationCell SizeG1 PhaseHumansRetinoblastoma ProteinRetinoblastoma Protein

Identifiers

PMID32703881
PMCPMC7489475
OpenAlexW3044410178

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.