ArticleThe journal of sexual medicine2020
Ovarian Histopathology in Transmasculine Persons on Testosterone: A Multicenter Case Series.
Article in The journal of sexual medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Transgender and gender diverse individuals embodying endometriosis: a systematic review.Frontiers in medicine · 2024Pooled it
- An Exploration of the Views and Perspectives of Australian Trans and Gender Diverse Individuals About Transvaginal Ultrasound.Perspectives on sexual and reproductive health · 2026Article
- Characterizing ovarian histopathology in transgender and gender-diverse patients on testosterone: Informing shared decision-making in gender-affirming care.Frontiers in reproductive health · 2026Article
- Oocyte cryopreservation for fertility preservation in transgender and gender diverse individuals: a SWOT analysis.Journal of assisted reproduction and genetics · 2025Review
- Fertility treatments in transgender individuals: trends, clinical outcomes, and impact of testosterone on ovarian stimulation.Journal of assisted reproduction and genetics · 2025Observational
- Gender-Affirming Hysterectomy and Oophorectomy Counseling Practices for Transmasculine Adolescents.Transgender health · 2025Article
- Article
- Uterine and Ovarian Histopathology After Testosterone for Gender Affirmation: A Systematic Review.Transgender health · 2024Review
- One-third of amenorrheic transmasculine people on testosterone ovulate.Cell reports. Medicine · 2024Article
- A Review of Animal Models Investigating the Reproductive Effects of Gender-Affirming Hormone Therapy.Journal of clinical medicine · 2024Review
- Clinical management of transgender and non-binary patients in the fertility preservation service: Current evidence.International journal of transgender health · 2024Review
- Cancer surveillance for transgender and gender diverse patients with Lynch syndrome: a practice resource of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer.Familial cancer · 2023Review
- Patient and Surgery Characteristics of Inpatient Hysterectomies Among Transgender Individuals.LGBT health · 2023Article
- Impaired in vitro fertilization outcomes following testosterone treatment improve with washout in a mouse model of gender-affirming hormone treatment.American journal of obstetrics and gynecology · 2023Article
- Preservation of Fertility in Transgender Men on Long-Term Testosterone Therapy: A Systematic Review of Oocyte Retrieval Outcomes During and After Exogenous Androgen Exposure.Transgender health · 2023Review
- Pelvic Pain in Transgender People Using Testosterone Therapy.LGBT health · 2023Article
- Fertility preservation options for transgender and nonbinary individuals.Therapeutic advances in endocrinology and metabolism · 2023Review
- Cervicovaginal cytology, HPV testing and vaginal flora in transmasculine persons receiving testosterone.Diagnostic cytopathology · 2022Article
- Fertility Preservation and Reproductive Potential in Transgender and Gender Fluid Population.Biomedicines · 2022Review
- Increased Surveillance or Increased Scrutiny: Curbing Inappropriate Screening of Endometrial Cancer in Transgender Men.Journal of family & reproductive health · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundAs transmasculine persons utilize androgen gender affirming hormone therapy as a part of transition, guidance has been lacking on the effects of the therapy on the ovaries, especially for those who may desire retention.
aimTo describe the ovarian histopathology of transmasculine persons on testosterone therapy following oophorectomy at the time of hysterectomy performed for gender affirmation.
methodsThis was a multicenter case series study of transmasculine patients on testosterone therapy who underwent hysterectomy with oophorectomy for gender affirmation between January 2015 and December 2017 at 5 tertiary care referral centers. Patients were identified by their current procedural and International Classification of Diseases codes. OUTCOMES: Pre-, perioperative, and pathologic data were obtained from the electronic medical records and ovarian tissue descriptions from pathology reports were grouped into the following classifications: (i) simple/follicular cysts; (ii) polycystic ovaries; (iii) complex cysts; (iv) endometriomas; (v) other masses; (vi) atrophy; and (vii) normal.
results85 patients were included in the study. At the time of oophorectomy, the mean age and body mass index of the cohort were 30.4 ± 8.4 years and 30.2 ± 7.3 kg/m CLINICAL IMPLICATIONS: The results of this study reported benign histopathology in ovaries of a large cohort of transmasculine persons on testosterone which should be included when counseling patients on ovarian retention, as transmasculine patients may choose to retain their ovaries while on testosterone for a variety of reasons (including no desire to undergo surgery, desire for backup sex steroids, and potential use for future fertility). STRENGTHS & LIMITATIONS: This is a large multicenter study seeking to address the uncertainty in present counseling surrounding ovarian conservation in transmasculine persons on testosterone therapy. Its limitations included its retrospective nature and inability to address ovarian function after testosterone discontinuance.
conclusionIn this cohort of transmasculine patients on testosterone therapy undergoing hysterectomy with oophorectomy for gender affirmation, ovarian histopathology was benign in all the specimens. Grimstad FW, Fowler KG, New EP, et al. Ovarian Histopathology in Transmasculine Persons on Testosterone: A Multicenter Case Series. J Sex Med 2020;17:1807-1818.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.