Evidence map›Paper›PMID 32703659›Full record

ReviewUltrasound in medicine & biology2020

Visualization of Microvascular Angiogenesis Using Dual-Frequency Contrast-Enhanced Acoustic Angiography: A Review.

Isabel G Newsome, Paul A Dayton

Abstract readReview
In one paragraph

Review in Ultrasound in medicine & biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Design and Fabrication of 1-D CMUT Arrays for Dual-Mode Dual-Frequency Acoustic Angiography Applications.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Isabel G NewsomeJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, USA.
Paul A DaytonJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina, USA. Electronic address: padayton@email.unc.edu.

Funding

Pre-doctoral Training Program in Integrative Vascular BiologyT32HL069768 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christopher P. Mack · 2002 to 2026
$9.7M
Academic-Industrial Partnership for Translation of Acoustic AngiographyR01CA189479 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAYTON, PAUL A · 2014 to 2025
$4.7M
Micro-tumor detection by quantifying tumor-induced vascular abnormalities (PQ-13)R01CA170665 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAYTON, PAUL A · 2012 to 2015
$2.2M
Dual-frequency intravascular arrays for functional imaging of atherosclerosisR01EB015508 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI JIANG, XIAONING · 2012 to 2015
$2.0M
Acoustic Angiography Using Dual-Frequency and Ultrawideband CMUT ArraysR01EB026897 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI DAYTON, PAUL A, ORALKAN, OMER · 2018 to 2021
$1.9M
Quantitative Ultrasound Analysis of Vascular Morphology for Cancer AssessmentR44CA165621 · NCI · KITWARE, INC. · PI AYLWARD, STEPHEN R, DAYTON, PAUL A · 2015 to 2016
$1.3M
Toward Clinical Translation of Acoustic Angiography: Optimization of Microvascular Ultrasound Imaging on a Novel Dual-frequency ArrayF31CA243177 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NEWSOME, ISABEL · 2019 to 2020
$74k
NCI NIH HHS F31 CA243177NCI NIH HHS R01 CA170665NCI NIH HHS R01 CA189479NCI NIH HHS R44 CA165621NHLBI NIH HHS T32 HL069768NIBIB NIH HHS R01 EB015508NIBIB NIH HHS R01 EB026897
6 · The paper itself

Abstract

Cancerous tumor growth is associated with the development of tortuous, chaotic microvasculature, and this aberrant microvascular morphology can act as a biomarker of malignant disease. Acoustic angiography is a contrast-enhanced ultrasound technique that relies on superharmonic imaging to form high-resolution 3-D maps of the microvasculature. To date, acoustic angiography has been performed with dual-element transducers that can achieve high contrast-to-tissue ratio and resolution in pre-clinical small animal models. In this review, we first describe the development of acoustic angiography, including the principle, transducer design, and optimization of superharmonic imaging techniques. We then detail several preclinical applications of this microvascular imaging method, as well as the current and future development of acoustic angiography as a pre-clinical and clinical diagnostic tool.

Indexed as

Contrast MediaAcousticsAngiographyAnimalsForecastingHumansMicrovesselsNeoplasmsNeovascularization, PathologicUltrasonographyContrast MediaAngiogenesisAngiographyContrast agentMicrobubblesMicrovasculatureUltrasound

Identifiers

PMID32703659
PMCPMC7608693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.