Evidence map›Paper›PMID 32703309›Full record

ArticleBMC research notes2020

Impact of prematurity and the CTG repeat length on outcomes in congenital myotonic dystrophy.

Yu Saito, Kenta Matsumura, Misao Kageyama, Yuichi Kato, Eiji Ohta, Kiyoaki Sumi, Takeshi Futatani, Taketoshi Yoshida

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Yu SaitoDivision of Neonatology, Maternal and Perinatal Center, Toyama University Hospital, Toyama, Japan.
Kenta MatsumuraToyama Regional Center for Japan Environment and Children's Study, University of Toyama, Toyama, Japan.
Misao KageyamaDepartment of Neonatology, OKAYAMA Medical Center, Okayama, Japan.
Yuichi KatoDepartment of Neonatology, Anjo Kosei Hospital, Aichi, Japan.
Eiji OhtaDepartment of Pediatrics, Fukuoka University, Fukuoka, Japan.
Kiyoaki SumiDepartment of Pediatrics, Aizenbashi Hospital, Osaka, Japan.
Takeshi FutataniDepartment of Pediatrics, Toyama Prefectural Central Hospital, Toyama, Japan.
Taketoshi YoshidaDivision of Neonatology, Maternal and Perinatal Center, Toyama University Hospital, Toyama, Japan. ytake@med.u-toyama.ac.jp.
Toyama University Hospital · JPAnjo Kosei Hospital · JPFukuoka University · JPOkayama Medical Center · JPToujinkai Hospital · JPToyama Prefectural Central Hospital · JPUniversity of Toyama · JP

Funding

Japan Society for the Promotion of Science 19K08248
6 · The paper itself

Abstract

objectivePatients with congenital myotonic dystrophy (CDM) tend to be born preterm. Although the CDM severity generally depends on the CTG repeat length, prematurity may also affect the prognosis in patients with CDM. Given that preterm birth is expected to increase the risk of CDM in newborns, we investigated the outcomes of newborns with CDM according to gestational age to assess prematurity and the CTG repeat length for predicting prognosis.

resultsWe assessed the outcomes of 54 infants with CDM using data collected from our hospitals and previously published studies. The patients were divided into mild and severe groups based on clinical outcomes. Logistic regression analysis was performed to estimate odds ratios (ORs) for CDM prognosis according to gestational age and the CTG repeat length and to construct a predictive model. Logistic regression analysis showed both the CTG repeat and gestational age were significantly associated with severe outcomes in patients with CDM (OR: 32.27, 95% CI 3.45-300.7; p = 0.002 and OR: 0.73, 95% CI 0.58-0.93; p = 0.0094, respectively). This predictive model for CDM prognosis exhibited good sensitivity (63%) and specificity (86%). Both prematurity and the CTG repeat length were significantly associated with the CDM severity.

Indexed as

Myotonic DystrophyPremature BirthFemaleHumansInfantInfant, NewbornPregnancyTrinucleotide Repeat ExpansionCTG repeatDiscrimination analysisMyotonic dystrophyPredicting prognosisPrematurity

Identifiers

PMID32703309
PMCPMC7379817
OpenAlexW3044142090

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.