Evidence map›Paper›PMID 32703300›Full record

ArticleBMC infectious diseases2020

Unusual presentation of fatal disseminated varicella zoster virus infection in a patient with lupus nephritis: a case report.

Veronica Vassia, Alessandro Croce, Paolo Ravanini, Monica Leutner, Chiara Saglietti, Stefano Fangazio, Marco Quaglia, Carlo Smirne

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Veronica VassiaDepartment of Translational Medicine, DiMet, Università del Piemonte Orientale, via Solaroli 17, 28100, Novara, Italy.
Alessandro CroceDepartment of Translational Medicine, DiMet, Università del Piemonte Orientale, via Solaroli 17, 28100, Novara, Italy.
Paolo RavaniniLaboratory of Molecular Virology, AOU Maggiore della Carità, Novara, Italy.
Monica LeutnerHistopathology Unit, AOU Maggiore della Carità, Novara, Italy.
Chiara SagliettiHistopathology Unit, AOU Maggiore della Carità, Novara, Italy.
Stefano FangazioDepartment of Translational Medicine, DiMet, Università del Piemonte Orientale, via Solaroli 17, 28100, Novara, Italy.
Marco QuagliaDepartment of Translational Medicine, DiMet, Università del Piemonte Orientale, via Solaroli 17, 28100, Novara, Italy.
Carlo SmirneDepartment of Translational Medicine, DiMet, Università del Piemonte Orientale, via Solaroli 17, 28100, Novara, Italy. carlo.smirne@med.uniupo.it.ORCID http://orcid.org/0000-0002-3338-5416
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe risk of life-threatening complications, such as visceral disseminated varicella zoster virus (VZV) infection, is greater in immunosuppressed individuals, such as systemic lupus erythematosus (SLE) patients. CASE PRESENTATION: Here, a case is reported of a Caucasian woman diagnosed with lupus nephritis and anti-phospholipid syndrome, who was subjected to mycophenolate mofetil and high-dose steroid remission-induction therapy. Two months later she developed abdominal pain followed by a fatal rapid multi-organ failure. As no typical skin rashes were evident, death was initially attributed to catastrophic anti-phospholipid syndrome. However, autopsy and virological examinations on archival material revealed a disseminated VZV infection.

conclusionsOverall, this case highlights the importance of having a high clinical suspicion of fatal VZV infections in heavily immunosuppressed SLE patients even when typical signs and symptoms are lacking.

Indexed as

Abdominal PainAntiphospholipid SyndromeFatal OutcomeFemaleHerpesvirus 3, HumanHerpes ZosterHumansImmunocompromised HostLupus NephritisMiddle AgedMycophenolic AcidReal-Time Polymerase Chain ReactionSteroidsMycophenolic AcidSteroidsHerpesvirusesImmunosuppressionLatent virus infectionsMultiple virus reactivationsMycophenolate mofetilSteroid therapySystemic lupus erythematosusVaricella zoster virus

Identifiers

PMID32703300
PMCPMC7376941
OpenAlexW3043850766

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.