ArticleTrials2020
Consistency of trial reporting between ClinicalTrials.gov and corresponding publications: one decade after FDAAA.
Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Systematic review with cross sectional comparative analysis identifies adverse event reporting discrepancies between ClinicalTrials.gov and published glaucoma randomized controlled trials.Scientific reports · 2025Pooled it
- Nonregistration, Discontinuation, and Nonpublication of Randomized Trials: A Systematic Review.JAMA network open · 2025Pooled it
- Discordant Information on Blinding in Trial Registries and Published Research: A Systematic Review.JAMA network open · 2024Pooled it
- Transparency in positive airway pressure therapy trials: an evaluation of reporting quality.Journal of comparative effectiveness research · 2026Article
- Evaluation of consistency in adverse event reporting between trial registry and publications in COVID-19 pharmacological intervention trials.International journal of clinical pharmacy · 2026Article
- Consistency Between Clinical Trial Registry Entries and Journal Publications in Transfusion Medicine: An Observational Study.Journal of clinical medicine · 2026Article
- Article
- Landscape analysis of pre-registered clinical trials involving classical psychedelics.Journal of psychopharmacology (Oxford, England) · 2026Review
- Article
- Concordance between clinical trial data use request proposals and corresponding publications: A cross-sectional study.Clinical trials (London, England) · 2025Article
- Clinical trial registration in India: 12% of drug regulatory trials are not registered, as required by law.Health research policy and systems · 2025Article
- Protocol publication rate and comparison between article, registry and protocol in RCTs.BMC medical research methodology · 2025Article
- Funding of evidence included within public comments submitted to inform Medicare national coverage determinations.Health affairs scholar · 2024Article
- A Novel Method for Deriving Adverse Event Prevalence in Randomized Controlled Trials: Potential for Improved Understanding of Benefit-Risk Ratio and Application to Drug Labels.Advances in therapy · 2024Article
- Availability of results of clinical trials registered on EU Clinical Trials Register: cross sectional audit study.BMJ medicine · 2024Article
- 15-year biochemical failure, metastasis, salvage therapy, and cancer-specific and overall survival rates in men treated with robotic radical prostatectomy for PSA-screen detected prostate cancer.Prostate cancer and prostatic diseases · 2023Article
- Dissemination of Registered COVID-19 Clinical Trials (DIRECCT): a cross-sectional study.BMC medicine · 2023Article
- Reporting characteristics of nonsurgical periodontal therapy trials registered in ClinicalTrials.gov: an observational study.Journal of comparative effectiveness research · 2023Observational
- Update on the clinical trial landscape: analysis of ClinicalTrials.gov registration data, 2000-2020.Trials · 2022Article
- Reporting of the safety from allergic rhinitis trials registered on ClinicalTrials.gov and in publications: An observational study.BMC medical research methodology · 2022Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The FDA Amendments Act (FDAAA) required that information for certain clinical trials, such as details about study design features and endpoints, as well as results, be publicly reported in ClinicalTrials.gov . We conducted a cross-sectional analysis of phase III trials with primary results published between January 1, 2016, and June 30, 2017, in high-impact journals and found 74% contained at least one discrepancy between results reported in ClinicalTrials.gov and the corresponding publication. Our findings underscore the necessity for monitoring of clinical trial information and result reporting between sources; a checklist may provide a systemized procedure for investigators and editors to monitor accurate reporting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.