Evidence map›Paper›PMID 32703248›Full record

ArticleJournal of orthopaedic surgery and research2020

Evaluation of genetic susceptibility of common variants in SOX9 in patients with congenital talipes equinovarus in the Han Chinese population.

Jian Li, Zhi Wang, Dongxu Feng, Wei Wang, Weilou Feng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jian LiDepartment of Sports Medicine, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Zhi WangDepartment of Neonatology, Xi'an Children Hospital, Xi'an, Shaanxi, China.
Dongxu FengDepartment of Orthopaedic Trauma, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wei WangDepartment of Sports Medicine, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Weilou FengDepartment of Orthopaedic Trauma, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China. fyannutri@163.com.ORCID http://orcid.org/0000-0003-3796-3524
Xi'an Honghui Hospital · CNXi’an Children’s Hospital · CN

Funding

Natural Science Foundation of Shaanxi Province 2018JQ3040
6 · The paper itself

Abstract

backgroundCongenital talipes equinovarus (CTEV) is a common birth defect that causes severe deformities of one or both feet. Genetics have been proven to play a key role in the risk of CTEV. Our study aimed to evaluate the genetic susceptibility of common variants in the SOX9 gene to CTEV in a Han Chinese population.

methodsIn this study, we recruited 2,205 study participants, including 692 CTEV patients and 1513 healthy controls. A total of seven selected single-nucleotide polymorphisms (SNPs) within the SOX9 gene were genotyped, and environmental variables, including maternal smoking and alcoholic drinking habits, were assessed. In addition, bioinformatics analyses were performed to explore the potential biological functions of the associated SNPs.

resultsThe SNP rs73354570 was identified to be significantly associated with the risk of CTEV (OR = 1.53, P = 2.11 × 10

conclusionOur results provide evidence supporting the important role of the SOX9 gene in the contribution to the risk of CTEV.

Indexed as

Genetic Association StudiesAsian PeopleCase-Control StudiesChildChild, PreschoolChinaClubfootFemaleGenetic Predisposition to DiseaseHumansInfantMalePolymorphism, Single NucleotideRiskSOX9 Transcription FactorSOX9 protein, humanSOX9 Transcription FactorCase-control studyCongenital talipes equinovarusGenetic associationSingle-nucleotide polymorphismsSOX9 gene

Identifiers

PMID32703248
PMCPMC7376870
OpenAlexW3043910984

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.