ArticleBMC plant biology2020
Integrated metabolomic and transcriptomic analysis of the anthocyanin regulatory networks in Salvia miltiorrhiza Bge. flowers.
Article in BMC plant biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58 citing papers in PubMed, 161 citations in OpenAlex.
- Temporal Partitioning of Carotenoid, Flavonoid and Anthocyanin Biosynthesis Underlies the Ontogenetic Petal Color Transition inMetabolites · 2026Article
- Integrated Transcriptomic and Metabolomic Analyses Reveal the Regulatory Drivers of Anthocyanin-Mediated Leaf Color Variation inInternational journal of molecular sciences · 2026Article
- Genome sequence of the ornamental plant Digitalis purpurea reveals the molecular basis of flower color and morphology variation.BMC genomics · 2026Article
- Integrated metabolome and transcriptome analyses reveal the role played by CaWRKY44 during anthocyanins accumulation in pepper fruits.BMC plant biology · 2026Article
- Metabolomics and Transcriptomics Analyses Explore the Genes Related to the Biosynthesis of Antioxidant Active Ingredient Isoquercetin.Foods (Basel, Switzerland) · 2026Article
- The chromosome-level genome of Hemerocallis middendorffii provides new insights into the floral scents and color biosynthesis in Chinese native daylily.BMC plant biology · 2025Article
- Integrated metabolomic and transcriptomic analysis of the anthocyanin regulatory networks in Lagerstroemia indica petals.BMC plant biology · 2025Article
- Preliminary Analysis of the Formation Mechanism of Floret Color in Broccoli (Plants (Basel, Switzerland) · 2025Article
- cDNA Cloning, Bioinformatics, and Expression Analysis ofInternational journal of molecular sciences · 2025Article
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- Time-series transcriptome analysis reveals the cascade mechanism of biological processes following the perturbation of the MVA pathway in Salvia miltiorrhiza.Plant molecular biology · 2025Article
- Integrated transcriptomic and metabolomic analyses reveal the molecular mechanism of flower color differentiation inFrontiers in plant science · 2025Article
- Transcriptomics and metabolomics revealed the molecular basis of the color formation in the roots ofHeliyon · 2024Article
- Biosynthesis and signal transduction of plant growth regulators and their effects on bioactive compound production in Salvia miltiorrhiza (Danshen).Chinese medicine · 2024Review
- Transcriptome sequencing and metabolome analysis reveal the molecular mechanism of Salvia miltiorrhiza in response to drought stress.BMC plant biology · 2024Article
- Integrative analysis of transcriptome and target metabolites uncovering flavonoid biosynthesis regulation of changing petal colors in Nymphaea 'Feitian 2'.BMC plant biology · 2024Article
- Article
- Integrative metabolome and transcriptome analyses reveal the coloration mechanism in Camellia oleifera petals with different color.BMC plant biology · 2024Article
- Integrated metabolome and transcriptome analyses of anthocyanin biosynthesis reveal key candidate genes involved in colour variation of Scutellaria baicalensis flowers.BMC plant biology · 2023Article
- Molecular mechanism of different flower color formation of Cymbidium ensifolium.Plant molecular biology · 2023Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objectives of this study were to reveal the anthocyanin biosynthesis metabolic pathway in white and purple flowers of Salvia miltiorrhiza using metabolomics and transcriptomics, to identify different anthocyanin metabolites, and to analyze the differentially expressed genes involved in anthocyanin biosynthesis.
resultsWe analyzed the metabolomics and transcriptomics data of S. miltiorrhiza flowers. A total of 1994 differentially expressed genes and 84 flavonoid metabolites were identified between the white and purple flowers of S. miltiorrhiza. Integrated analysis of transcriptomics and metabolomics showed that cyanidin 3,5-O-diglucoside, malvidin 3,5-diglucoside, and cyanidin 3-O-galactoside were mainly responsible for the purple flower color of S. miltiorrhiza. A total of 100 unigenes encoding 10 enzymes were identified as candidate genes involved in anthocyanin biosynthesis in S. miltiorrhiza flowers. Low expression of the ANS gene decreased the anthocyanin content but enhanced the accumulation of flavonoids in S. miltiorrhiza flowers.
conclusionsOur results provide valuable information on the anthocyanin metabolites and the candidate genes involved in the anthocyanin biosynthesis pathways in S. miltiorrhiza.
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