Evidence map›Paper›PMID 32703069›Full record

ArticleHuman vaccines & immunotherapeutics2020

Promise and challenges in the development of COVID-19 vaccines.

Wangxue Chen

Open access · greenAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
0.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 46 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. COVID-19 vaccination: Is it a matter of concern?Journal of family medicine and primary care · 2022
    Article
  8. Mind the "Vaccine Fatigue".Frontiers in immunology · 2022
    Review
  9. Roborovski hamsterVirulence · 2021
    Article
  10. Article
  11. Article
  12. Public Knowledge, Attitude, and Perception towards COVID-19 Vaccination in Saudi Arabia.International journal of environmental research and public health · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Wangxue ChenHuman Health Therapeutics Research Center (HHT), National Research Council Canada , Ottawa, Ontario, Canada.ORCID 0000-0003-0958-7728
Brock University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pandemic outbreak of COVID-19, caused by coronavirus SARS-CoV-2, created an unprecedented challenge to global public health system and biomedical community. Vaccination is an effective way to prevent viral infection, stop its transmission, and develop herd immunity. Rapid progress and advances have been made to date in the development of COVID-19 vaccines. Currently, more than 115 vaccine candidates have been developed from different technology platforms with several of them in clinical trials. Most of those vaccine candidates are developed based on the experience with other coronaviruses with an aim to induce neutralizing antibodies against the viral spike protein or its different receptor binding domains. Here, we discuss the promise, potential scientific challenges, and future directions for the development of a safe and effective COVID-19 vaccine. We also emphasize the importance of a better understanding of the infection pathogenesis and host defense mechanisms against SARS-CoV-2 infection.

Indexed as

Antibody-Dependent EnhancementCOVID-19COVID-19 VaccinesHumansImmunity, HerdSARS-CoV-2Spike Glycoprotein, CoronavirusVaccinationViral LoadCOVID-19 VaccinesSpike Glycoprotein, Coronavirusanimal modelCOVID-19protective immunitysafetySARS-COV-2vaccine

Identifiers

PMID32703069
PMCPMC7733917
OpenAlexW3043912851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.