ArticlePhysics in medicine and biology2020
Dual source hybrid spectral micro-CT using an energy-integrating and a photon-counting detector.
Article in Physics in medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Virtual photon-counting micro-CT platform for simulation of head and neck cancer imaging in mice.Physics in medicine and biology · 2026Article
- Image-Guided Cardiac Regeneration via a 3D Bioprinted Vascular Patch with Built-in CT Visibility.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2025Article
- Development of anatomically variable digital Wistar rat phantoms for small animal imaging research.Medical physics · 2025Article
- Article
- Assessing the cardioprotective effects of exercise in APOE mouse models using deep learning and photon-counting micro-CT.PloS one · 2025Article
- Triple-source saddle-curve cone-beam photon counting CT image reconstruction: A simulation study.Zeitschrift fur medizinische Physik · 2024Article
- Leveraging 3D Bioprinting and Photon-Counting Computed Tomography to Enable Noninvasive Quantitative Tracking of Multifunctional Tissue Engineered Constructs.Advanced healthcare materials · 2023Article
- A Deep Learning Approach for Rapid and Generalizable Denoising of Photon-Counting Micro-CT Images.Tomography (Ann Arbor, Mich.) · 2023Article
- Advanced photon counting CT imaging pipeline for cardiac phenotyping of apolipoprotein E mouse models.PloS one · 2023Article
- Material decomposition from photon-counting CT using a convolutional neural network and energy-integrating CT training labels.Physics in medicine and biology · 2022Article
- Nanoparticle Contrast Agents for Photon-Counting Computed Tomography: Recent Developments and Future Opportunities.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Preclinical micro-CT provides a hotbed in which to develop new imaging technologies, including spectral CT using photon counting detector (PCD) technology. Spectral imaging using PCDs promises to expand x-ray CT as a functional imaging modality, capable of molecular imaging, while maintaining CT's role as a powerful anatomical imaging modality. However, the utility of PCDs suffers due to distorted spectral measurements, affecting the accuracy of material decomposition. We attempt to improve material decomposition accuracy using our novel hybrid dual-source micro-CT system which combines a PCD and an energy integrating detector. Comparisons are made between PCD-only and hybrid CT results, both reconstructed with our iterative, multi-channel algorithm based on the split Bregman method and regularized with rank-sparse kernel regression. Multi-material decomposition is performed post-reconstruction for separation of iodine (I), gold (Au), gadolinium (Gd), and calcium (Ca). System performance is evaluated first in simulations, then in micro-CT phantoms, and finally in an in vivo experiment with a genetically modified p53
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.