ArticleNeuroImage. Clinical2020
Alterations in the metabolic networks of temporal lobe epilepsy patients: A graph theoretical analysis using FDG-PET.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives.Frontiers in neurology · 2022Pooled it
- Quantitative dual-tracerEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Early diagnosis of Alzheimer's Disease: Graph theoretical analysis of cerebellar network features based on 18F-AV45 PET.PloS one · 2026Article
- Comparing three methodologies for network analysis of human [EJNMMI research · 2025Article
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- [European journal of nuclear medicine and molecular imaging · 2025Article
- Distinct bone metabolic networks identified inFrontiers in medicine · 2025Article
- Intrinsic prefrontal functional connectivity according to cognitive impairment in patients with end-stage renal disease.Kidney research and clinical practice · 2024Article
- Individual cerebellar metabolic connectome in patients with MTLE and NTLE associated with surgical prognosis.European journal of nuclear medicine and molecular imaging · 2024Article
- Functional Connectivity Alterations in Patients with Post-stroke Epilepsy Based on Source-level EEG and Graph Theory.Brain topography · 2024Article
- Difference in functional connectivity between end-stage renal disease patients with and without restless legs syndrome: A prospective study.Sleep & breathing = Schlaf & Atmung · 2024Article
- Metabolic connectivity as a predictor of surgical outcome in mesial temporal lobe epilepsy.Epilepsia open · 2024Article
- Similarity between structural and proxy estimates of brain connectivity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Individual metabolic brain network abnormalities associated with drug-resistant mTLE vary in surgical outcomes.Frontiers in neurology · 2024Article
- Metabolic profiles and correlation with surgical outcomes in mesial versus neocortical temporal lobe epilepsy.CNS neuroscience & therapeutics · 2023Article
- Altered Metabolic Networks in Mesial Temporal Lobe Epilepsy with Focal to Bilateral Seizures.Brain sciences · 2023Article
- Structural brain network analysis in occipital lobe epilepsy.BMC neurology · 2023Article
- Individual Brain Metabolic Connectome Indicator Based on Jensen-Shannon Divergence Similarity Estimation Predicts Seizure Outcomes of Temporal Lobe Epilepsy.Frontiers in cell and developmental biology · 2021Article
- Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia.NeuroImage. Clinical · 2021Article
- Abnormal cerebral metabolism and metabolic connectivity in individuals with heroin dependence: an integrated resting-state PET/fMRI study in large-scale networks.Journal of psychiatry & neuroscience : JPNArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study is to investigate changes in metabolic networks based on fluorodeoxyglucose positron emission tomography (FDG-PET) in patients with drug-resistant temporal lobe epilepsy (TLE) (with and without hippocampal sclerosis [HS]) when compared with healthy controls.
methodsWe retrospectively enrolled 30 patients with drug-resistant temporal lobe epilepsy (17 patients with HS and 13 patients without HS) and 39 healthy controls. All subjects underwent interictal FDG-PET scans, which were analyzed to obtain metabolic connectivity using graph theoretical analysis. We investigated the differences in metabolic connectivity between patients with drug-resistant TLE (with and without HS) and healthy controls.
resultsWhen compared with healthy controls, TLE patients with HS showed alterations of global and local metabolic connectivity. When considering global connectivity, TLE patients with HS had a decreased average degree with increased modularity. When considering local connectivity, TLE patients with HS displayed alterations of betweeness centrality in widespread regions. However, there were no alterations of global metabolic connectivity in TLE patients without HS when compared with healthy controls. In addition, when compared to TLE patients without HS, TLE patients with HS had increased modularity. SIGNIFICANCE: Our study demonstrates more severe alterations in metabolic networks based on FDG-PET in TLE patients with HS than in those without HS and healthy controls. This may represent distinct epileptic networks in TLE patients with HS versus those without HS, although both are drug-resistant focal epilepsy.
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