Evidence map›Paper›PMID 32702486›Full record

ArticleNeuroImage2020

Cortical surface registration using unsupervised learning.

Jieyu Cheng, Adrian V Dalca, Bruce Fischl, Lilla Zöllei, Alzheimer’s Disease Neuroimaging Initiative

Abstract read
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. DEEP-LEARNING CORTICAL REGISTRATION GUIDED BY STRUCTURAL AND DIFFUSION MRI AND CONNECTIVITY.Proceedings. IEEE International Symposium on Biomedical Imaging · 2026
    Article
  2. Article
  3. Unified Brain Surface and Volume Registration.... International Conference on Learning Representations · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jieyu ChengA.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, USA.
Adrian V DalcaA.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, USA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, USA.
Bruce FischlA.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, USA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, USA.
Lilla ZölleiA.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, USA. Electronic address: lzollei@nmr.mgh.harvard.edu.
Alzheimer’s Disease Neuroimaging Initiative

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI William J. Jagust · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
Mapping the Human Connectome During Typical DevelopmentU01MH109589 · NIMH · WASHINGTON UNIVERSITY · PI BARCH, DEANNA, BOOKHEIMER, SUSAN Y · 2016 to 2019
$17.1M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
MRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5M
The Human Connectome Project (HCP)U01MH093765 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2010 to 2014
$12.1M
The Late Effects of TBI (LETBI) Study: Injury Patterns and Biological Markers of Post-Traumatic NeurodegenerationRF1NS115268 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Kristen Dams-O'Connor · 2019 to 2026
$10.3M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Imaging and Analysis Techniques to Construct a Cell Census Atlas of the Human Brain Admin SupplementU01MH117023 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A, FISCHL, BRUCE · 2018 to 2022
$7.6M
Longitudinal Study of childhood fMRI markers prior to reading onsetR01HD065762 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI GAAB, NADINE, GRANT, PATRICIA ELLEN · 2011 to 2021
$6.3M
Neuropathology of CTE and Delayed Effects of TBI: Toward In-Vivo DiagnosticsU01NS086625 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN · 2014 to 2017
$6.1M
NCRR NIH HHS S10 RR019307NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG064027NIA NIH HHS R56 AG064027NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG024904NIBIB NIH HHS P41 EB015896NIBIB NIH HHS R01 EB006758NIBIB NIH HHS R01 EB019956NIBIB NIH HHS R01 EB023281NIBIB NIH HHS R01 EB024343NIBIB NIH HHS R03 EB022754NIBIB NIH HHS R21 EB018907NICHD NIH HHS R01 HD065762NICHD NIH HHS R01 HD085813NICHD NIH HHS R01 HD093578NICHD NIH HHS R21 HD095338NIDDK NIH HHS R21 DK108277NIMH NIH HHS U01 MH093765NIMH NIH HHS U01 MH109589NIMH NIH HHS U01 MH117023NINDS NIH HHS R01 NS052585NINDS NIH HHS R01 NS070963NINDS NIH HHS R01 NS083534NINDS NIH HHS R01 NS105820NINDS NIH HHS R21 NS072652NINDS NIH HHS RF1 NS115268NINDS NIH HHS U01 NS086625
6 · The paper itself

Abstract

Non-rigid cortical registration is an important and challenging task due to the geometric complexity of the human cortex and the high degree of inter-subject variability. A conventional solution is to use a spherical representation of surface properties and perform registration by aligning cortical folding patterns in that space. This strategy produces accurate spatial alignment, but often requires high computational cost. Recently, convolutional neural networks (CNNs) have demonstrated the potential to dramatically speed up volumetric registration. However, due to distortions introduced by projecting a sphere to a 2D plane, a direct application of recent learning-based methods to surfaces yields poor results. In this study, we present SphereMorph, a diffeomorphic registration framework for cortical surfaces using deep networks that addresses these issues. SphereMorph uses a UNet-style network associated with a spherical kernel to learn the displacement field and warps the sphere using a modified spatial transformer layer. We propose a resampling weight in computing the data fitting loss to account for distortions introduced by polar projection, and demonstrate the performance of our proposed method on two tasks, including cortical parcellation and group-wise functional area alignment. The experiments show that the proposed SphereMorph is capable of modeling the geometric registration problem in a CNN framework and demonstrate superior registration accuracy and computational efficiency. The source code of SphereMorph will be released to the public upon acceptance of this manuscript at https://github.com/voxelmorph/spheremorph.

Indexed as

AgingDeep LearningModels, TheoreticalUnsupervised Machine LearningAdultAgedAged, 80 and overAlzheimer DiseaseCerebral CortexCognitive DysfunctionFemaleHumansMagnetic Resonance ImagingMaleNeuroimagingYoung AdultCortical surface registrationDeep learningSphereMorphSubject-to-atlas registrationUnsupervised learning

Identifiers

PMID32702486
PMCPMC7784120

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.