ArticleJournal of dental research2020
Transcriptomic Classification of Neurons Innervating Teeth.
Article in Journal of dental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Hypomineralized Enamel Alters Trigeminal Sensory Afferent Architecture, Transcriptome, and Dental Injury Responses.bioRxiv : the preprint server for biology · 2026Article
- Review
- Protocol for targeted peripheral adeno-associated viral vector transduction of the intradental neurons in mice.STAR protocols · 2026Article
- An Implanted Tooth That Can Feel.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Somatosensory Functions of Melastatin Transient-Receptor Potential Channels in the Teeth: Molecular Basis for Thermal Dentine Hypersensitivity.Dentistry journal · 2026Review
- Protocol for the precise activation of intradental neurons in mice via electrical stimulation.STAR protocols · 2026Article
- Tooth Pulp Afferents and Transient Receptor Potential (TRP) Ion Channels as Key Regulators of Pulp Homeostasis, Inflammation, and Pain.International journal of molecular sciences · 2025Review
- Article
- Nerve Types and Classification of Neurons Innervating Oral Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Functional and distinct roles of Piezo2-mediated mechanotransduction in dental primary afferent neurons.International journal of oral science · 2025Article
- Sensory innervation of rat molar root pulp and dentin, apex, foramen, cellular cementum, vasculature and periodontium.Archives of oral biology · 2025Article
- Trigeminal somatosensation in the temporomandibular joint and associated disorders.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- The anatomy, neurophysiology, and cellular mechanisms of intradental sensation.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Transcriptional profiling of dental sensory and proprioceptive trigeminal neurons using single-cell RNA sequencing.International journal of oral science · 2023Article
- Nociceptors are needed to guide tooth development, function, repair, and regeneration.Neural regeneration research · 2023Article
- Neural signalling of gut mechanosensation in ingestive and digestive processes.Nature reviews. Neuroscience · 2022Review
- Article
- Trigeminal sensory nerve patterns in dentine and their responses to attrition in rat molars.Archives of oral biology · 2021Article
- The Form and Function of PIEZO2.Annual review of biochemistry · 2021Review
- The dental pulp as a high-resolution model for neurovascular niche biology.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Toothache is a common painful consequence of damage to the teeth, particularly when coupled to infection. Clinical restoration of tooth integrity, sometimes involving physical and chemical sterilization of the tooth with nerve fiber ablation (i.e., endodontic therapy), generally alleviates pain and allows long-lasting dental function. These observations raise questions regarding the biological role of tooth-innervating fibers. Here, we determined the transcriptomic diversity of the sensory neurons that can be retrogradely labeled from mouse molar teeth. Our results demonstrate that individual molars are each targeted by a dedicated population of about 50 specialized trigeminal neurons. Transcriptomic profiling identifies the majority of these as expressing markers of fast-conducting neurons, with about two-thirds containing nociceptive markers. Our data provide a new view of dental innervation, extending previous reports that used candidate gene approaches. Importantly, almost all retrogradely labeled neurons, including nociceptors, express the recently characterized mechanosensor Piezo2, an ion channel that endows cells with sensitivity to gentle touch. Intriguingly, about a quarter of the labeled neurons do not appear to be nociceptors, perhaps insinuating a role for them in discriminative touch. We hypothesize that dental neurons are capable of providing mechanosensitive information to drive rapid behavioral responses and protect teeth from damage. Damage to the teeth and exposure of the large population of molar nociceptors may trigger prolonged or abnormal activation driving toothache. Future studies examining the responses of these transcriptomically defined classes of neurons will help define their significance in oral sensation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.