Evidence map›Paper›PMID 32702219›Full record

ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2020

Effectiveness of Stimulant Medications on Disruptive Behavior and Mood Problems in Young Children.

Ian Parsley, Zhuo Zhang, Mark Hausmann, Arica Lerdahl, Brigette Vaughan, Ryan Edwards, Soonjo Hwang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ian ParsleyDepartment of Psychiatry, Washington University, St. Louis, MO, USA.ORCID https://orcid.org/0000-0003-2431-6731
Zhuo ZhangChina University of Political Science and Law, School of Psychology, Beijing, China.ORCID https://orcid.org/0000-0002-1367-4106
Mark HausmannDaybreak Mental and Behavioral Health, Papillion, NE, USA.ORCID https://orcid.org/0000-0002-6129-356X
Arica LerdahlDepartment of Psychiatry, University of Nebraska Medical Center, Omaha, NE, USA.ORCID https://orcid.org/0000-0002-6665-423X
Brigette VaughanDepartment of Psychiatry, University of Nebraska Medical Center, Omaha, NE, USA.ORCID https://orcid.org/0000-0002-8578-9826
Ryan EdwardsDepartment of Psychiatry, University of Nebraska Medical Center, Omaha, NE, USA.ORCID https://orcid.org/0000-0001-9823-0872
Soonjo HwangDepartment of Psychiatry, University of Nebraska Medical Center, Omaha, NE, USA.ORCID https://orcid.org/0000-0001-5117-2468
University of Nebraska Medical Center · USChina University of Political Science and Law · CNWashington University in St. Louis · US

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ESTABROOKS, PAUL · 2016 to 2025
$42.8M
Dose-Response Relationship and Pharmacokinetics of Intranasal Oxytocin on Neural Impact in Youths with High Levels of IrritabilityU01MH120155 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HWANG, SOONJO, SHAFFER, CHRISTOPHER LEE · 2020 to 2022
$2.3M
NIGMS NIH HHS U54 GM115458NIMH NIH HHS U01 MH120155
6 · The paper itself

Abstract

objectiveThere are very few studies on the effectiveness of stimulant medications for the treatment of disruptive mood and behavior problems in young children (less than 7 years) with Disruptive Behavior Disorders (DBD). The current study aims to determine whether young children (ages 4-7) in a long-term, intensive outpatient behavioral treatment program who are receiving stimulant medications show greater improvement in mood and behavior problems compared to peers who did not.

methodsA retrospective chart review was conducted for 97 participants diagnosed with DBD, aged 4-7 years old who were enrolled in an intensive outpatient behavioral intervention program. Pre- and post-intervention Child Behavior Checklist (CBCL) scores for disruptive behavior and mood problems were compared between the children who received stimulant medications and those who did not.

resultsPaired t tests showed a statistically significant improvement in CBCL outcomes between pre- and post-intervention scores of disruptive behavior and mood problems. ANCOVA analysis, however, showed no clear further improvement in those same CBCL scores in the participants who received stimulant medications compared to the participants who did not. CBCL scores for Conduct Disorder were marginally significant for less improvement for the participants who received stimulant medications.

conclusionThis retrospective review suggests a possibility that stimulant medications may not provide additional benefit for the long-term treatment of disruptive behavior and mood problems in young children under age 7. Future study is warranted to evaluate the efficacy/effectiveness of stimulant medications in the treatment of disruptive behavior and mood problems in this population.

Indexed as

AggressionDisruptive behaviorEffectivenessStimulant medicationYoung children

Identifiers

PMID32702219
PMCPMC7383001
OpenAlexW3044599075

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.