ArticleInternational forum of allergy & rhinology2021
Elevated mucus interleukin-17A levels are associated with increased prior sinus surgery for chronic rhinosinusitis.
Article in International forum of allergy & rhinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- High Radiological Severity in CRSwNP Is Associated With a Mixed Type 2/Type 3 Epithelial Inflammatory Signature.Laryngoscope investigative otolaryngology · 2026Article
- Establishing the PMThe Journal of allergy and clinical immunology · 2026Article
- Predictive Modeling of Surgically Recalcitrant Chronic Rhinosinusitis Using Integrated Feature Sets.Ear, nose, & throat journal · 2025Article
- Recurrence of Chronic Rhinosinusitis with Nasal Polyps After Surgery: Risk Factors, Predictive Models, and Treatment Approaches with a Focus on Western and Asian Differences.Medicina (Kaunas, Lithuania) · 2025Review
- Effects of inflammatory endotypes on disease trajectory in chronic rhinosinusitis with nasal polyps.The Journal of allergy and clinical immunology · 2025Article
- Expression and correlation of SOCS3 and Eotaxin mRNA and proteins levels in nasal mucosal tissue of allergic rhinitis patients.Frontiers in immunology · 2025Article
- All chronic rhinosinusitis endotype clusters demonstrate improvement in patient-reported and clinical outcome measures after endoscopic sinus surgery.International forum of allergy & rhinology · 2024Observational
- Inflammatory characteristics of central compartment atopic disease.International forum of allergy & rhinology · 2023Article
- Epithelial innate immune response to Pseudomonas aeruginosa-derived flagellin in chronic rhinosinusitis.International forum of allergy & rhinology · 2023Article
- Chronic rhinosinusitis with nasal polyps management in the biologic therapy era: an international YO-IFOS survey.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- [Research progress of biomarkers in nasal secretions in endotypes diagnosis and clinical application of chronic rhinosinusitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Review
- Current insight into treatment of chronic rhinosinusitis: Phenotypes, endotypes, and implications for targeted therapeutics.The Journal of allergy and clinical immunology · 2022Review
- Utility of nasal mucus inflammatory profile as a biomarker of nasal polyp regrowth in aspirin-exacerbated respiratory disease.The journal of allergy and clinical immunology. In practice · 2022Article
- Management of Chronic Rhinosinusitis with Nasal Polyposis in the Era of Biologics.Journal of asthma and allergy · 2021Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecent advances in molecular biology have enabled the identification of potential inflammatory endotypes of chronic rhinosinusitis (CRS), with prior work suggesting differential short-term surgical outcome trajectories based on cytokine signatures. However, there is a paucity of data assessing long-term treatment failure and need for revision surgery based on inflammatory biomarkers.
methodsRetrospective analysis of prospectively collected cross-sectional data from 231 patients electing surgical therapy for CRS. Intraoperative mucus specimens were quantitatively sampled for inflammatory cytokines using a multiplex flow cytometric bead assay. Univariate Spearman correlations between cytokine levels and prior number of surgeries were assessed. A stepwise adjusted multivariate Poisson regression analysis was used to model patient-reported prior sinus surgery counts as a function of cytokine levels.
resultsSeveral cytokines (interleukin [IL]-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IL-17A, tumor necrosis factor α [TNF-α], interferon γ [IFN-γ], and eotaxin) demonstrated significant positive correlations with number of prior surgeries. However, only higher IL-17A levels were independently associated with a higher number of prior sinus surgeries (β = 0.345, p = 0.0003) after adjusting for the significant covariates of age (β = 0.018, p = 0.0036), Lund-Mackay score (β = -0.046, p = 0.02), history of aspirin-exacerbated respiratory disease (β = 1.01, p < 0.0001) and allergic fungal rhinosinusitis (β = 1.08, p < 0.0001). Higher levels of regulated on activation, normal T-cell expressed and secreted (RANTES) were conversely associated with a lower number of prior surgeries (β = -0.17, p = 0.048).
conclusionAn IL-17A-predominant cytokine profile is linked to an increased number of prior sinus surgeries. Thus, type 3 inflammatory markers may indicate a particularly difficult-to-treat, recalcitrant CRS endotype.
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