ArticlePloS one2020
A multi-scale modelling framework combining musculoskeletal rigid-body simulations with adaptive finite element analyses, to evaluate the impact of femoral geometry on hip joint contact forces and femoral bone growth.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- A Simplified Model of the Knee for Coronal Plane Alignment of the Knee Simulation.Bioengineering (Basel, Switzerland) · 2026Article
- A Musculoskeletal-Finite Element Study of Knee Joint Loading and Cartilage Mechanics in Children with Cerebral Palsy.Annals of biomedical engineering · 2026Article
- Computational mechanobiological model combining epiphyseal, apophyseal, and appositional growth and inner bone remodeling of the juvenile femur.Biomedical engineering online · 2026Article
- Reproducible Research: Computational Design of Personalized Clinical Treatments for Walking Impairments Using the Neuromusculoskeletal Modeling Pipeline.bioRxiv : the preprint server for biology · 2026Article
- Do we need medical imaging-informed musculoskeletal models for simulations in healthy adults? A new workflow based on magnetic resonance imaging highlights the importance of personalized geometry.PLoS computational biology · 2026Article
- Finite element analysis of the proximal femoral growth plate biomechanics: insights into cam deformity risk of adolescent athletes.Frontiers in sports and active living · 2026Article
- Understanding the influence of geometry and material properties on femoral and tibial stress and strain analysis in a paediatric population for single-leg standing simulation.Frontiers in bioengineering and biotechnology · 2026Article
- Foot progression angle modifications alter hip joint contact forces and femoral growth plate mechanics in children.Frontiers in bioengineering and biotechnology · 2026Article
- Prediction accuracy of femoral and tibial stress and strain using statistical shape and density model-based finite element models in paediatrics.Biomechanics and modeling in mechanobiology · 2025Article
- Femoral bone growth predictions based on personalized multi-scale simulations: validation and sensitivity analysis of a mechanobiological model.Biomechanics and modeling in mechanobiology · 2025Article
- How compactness affects long bone resistance to compression-An investigation into the rhinoceros humerus.Journal of anatomy · 2025Article
- Comparative finite element analysis of fixation strategies for sports-related tibial tuberosity avulsion fractures in adolescents: biomechanical evidence for optimized clinical decision-making.Frontiers in sports and active living · 2025Article
- Effect of femoral derotational osteotomy in patients with idiopathic increased femoral anteversion on joint loading and muscular demands.Journal of children's orthopaedics · 2024Article
- Understanding the role of head size and neck length in micromotion generation at the taper junction in total hip arthroplasty.Scientific reports · 2024Article
- A framework based on subject-specific musculoskeletal models and Monte Carlo simulations to personalize muscle coordination retraining.Scientific reports · 2024Article
- Comparison of Locked Plates and Blade Plates for Varus Osteotomy of the Proximal Femur by the Finite Element Method.Revista brasileira de ortopedia · 2024Article
- Mechanical Biomarkers in Bone Using Image-Based Finite Element Analysis.Current osteoporosis reports · 2023Review
- Influence of femoral anteversion angle and neck-shaft angle on muscle forces and joint loading during walking.PloS one · 2023Article
- The gait pattern and not the femoral morphology is the main contributor to asymmetric hip joint loading.PloS one · 2023Article
- Intra- and inter-subject variability of femoral growth plate stresses in typically developing children and children with cerebral palsy.Frontiers in bioengineering and biotechnology · 2023Article
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8 authors.
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Abstract
Multi-scale simulations, combining muscle and joint contact force (JCF) from musculoskeletal simulations with adaptive mechanobiological finite element analysis, allow to estimate musculoskeletal loading and predict femoral growth in children. Generic linearly scaled musculoskeletal models are commonly used. This approach, however, neglects subject- and age-specific musculoskeletal geometry, e.g. femoral neck-shaft angle (NSA) and anteversion angle (AVA). This study aimed to evaluate the impact of proximal femoral geometry, i.e. altered NSA and AVA, on hip JCF and femoral growth simulations. Musculoskeletal models with NSA ranging from 120° to 150° and AVA ranging from 20° to 50° were created and used to calculate muscle and hip JCF based on the gait analysis data of a typically developing child. A finite element model of a paediatric femur was created from magnetic resonance images. The finite element model was morphed to the geometries of the different musculoskeletal models and used for mechanobiological finite element analysis to predict femoral growth trends. Our findings showed that hip JCF increase with increasing NSA and AVA. Furthermore, the orientation of the hip JCF followed the orientation of the femoral neck axis. Consequently, the osteogenic index, which is a function of cartilage stresses and defines the growth rate, barely changed with altered NSA and AVA. Nevertheless, growth predictions were sensitive to the femoral geometry due to changes in the predicted growth directions. Altered NSA had a bigger impact on the growth results than altered AVA. Growth simulations based on mechanobiological principles were in agreement with reported changes in paediatric populations.
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