Evidence map›Paper›PMID 32701949›Full record

ArticlePloS one2020

Development of a definition and rules for causal attribution of post-colonoscopy bleeding.

Robert J Hilsden, Courtney M Maxwell, Nauzer Forbes, Ronald J Bridges, Alaa Rostom, Catherine Dube, Devon Boyne, Darren Brenner, Steven J Heitman

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06393868 (Reducing Gastrointestinal Bleeding With Proton Pump Inhibitor Therapy in Acute Venous Thromboembolism), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06393868 phase3recruitingnot on this mapstarted 2024, after this paper: background citation

Reducing Gastrointestinal Bleeding With Proton Pump Inhibitor Therapy in Acute Venous Thromboembolism: Pilot Randomized Study (RADIANT Study)

TypeinterventionalSponsorOttawa Hospital Research InstituteRan2024 to 2028Enrolled360ConditionsVenous Thromboembolism, Gastro Intestinal Bleeding, Blood ClotArmsOmeprazole 20 mg Oral Tablet, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Quality Indicators Common to All Gastrointestinal Endoscopic Procedures.The American journal of gastroenterology · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Robert J HilsdenDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0003-1545-1093
Courtney M MaxwellForzani & MacPhail Colon Cancer Screening Centre, Alberta Health Services, Calgary, AB, Canada.ORCID 0000-0001-5213-6493
Nauzer ForbesDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0002-6966-3908
Ronald J BridgesDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Alaa RostomDepartment of Medicine, University of Ottawa, Ottawa, ON, Canada.
Catherine DubeDepartment of Medicine, University of Ottawa, Ottawa, ON, Canada.
Devon BoyneDepartment of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Darren BrennerDepartment of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Steven J HeitmanDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-colonoscopy bleeding (PCB) is an important colonoscopy quality indicator that is recommended to be routinely collected by colorectal cancer screening programs and endoscopy quality improvement programs. We created a standardized and reliable definition of PCB and set of rules for attributing the relatedness of PCB to a colonoscopy.

methodsPCB events were identified from colonoscopies performed at the Forzani & MacPhail Colon Cancer Screening Centre. Existing definitions and relatedness rules for PCB were reviewed by the authors and a draft definition and set of rules was created. The definition and rules were revised after initial testing was performed using a set of 15 bleeding events. Information available for each event included the original endoscopy report and data abstracted from the emergency or inpatient record by a trained research assistant. A validation set of 32 bleeding events were then reviewed to assess their interrater reliability by having three endoscopists and one research assistant complete independent reviews and three endoscopists complete a consensus review. The Kappa statistic was used to measure interrater reliability.

resultsThe panel classified 28 of 32 events as meeting the definition of PCB and rated 7, 8 and 6 events as definitely, probably and possibly related to the colonoscopy, respectively. The Kappa for the definition of PCB for the three independent reviews was 0.82 (substantial agreement). The Kappa for the attribution of the PCB to the colonoscopy by the three endosocopists was 0.74 (substantial agreement). The research assistant had a high agreement with the panel for both the definition (100% agreement) and application of the causal criteria (kappa 0.95).

conclusionsA standardized definition of PCB and attribution rules achieved high interrater reliability by endoscopists and a non-endoscopist and provides a template of required data for event adjudication by screening and quality improvement programs.

Indexed as

Colonic NeoplasmsColonic PolypsColonoscopyHemoglobinsHemorrhageHumansHemoglobins

Identifiers

PMID32701949
PMCPMC7377473

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.