Evidence map›Paper›PMID 32701550›Full record

Observational studyCritical care medicine2020

Full Finger Reperfusion Time Measured by Pulse Oximeter Waveform Analysis in Children.

Amanda J Nickel, Shen Jiang, Natalie Napolitano, Nadir Yehya, Julie C Fitzgerald, Benjamin B Bruins, Justin L Lockman, Vinay M Nadkarni, Akira Nishisaki

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Amanda J NickelDepartment of Respiratory Care, Children's Hospital of Philadelphia, Philadelphia, PA.
Shen JiangNihon Kohden Innovation Center, Boston, MA.
Natalie NapolitanoDepartment of Respiratory Care, Children's Hospital of Philadelphia, Philadelphia, PA.
Nadir YehyaDepartment of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA.
Julie C FitzgeraldDepartment of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA.
Benjamin B BruinsDepartment of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA.
Justin L LockmanDepartment of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA.
Vinay M NadkarniDepartment of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA.
Akira NishisakiDepartment of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Clinical and Proteomic Characterization of Nucleosomes in Pediatric Acute Respiratory Distress SyndromeK23HL136688 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI YEHYA, NADIR · 2017 to 2020
$694k
NHLBI NIH HHS K23 HL136688
6 · The paper itself

Abstract

objectivesCapillary refill time is a noninvasive method to assess tissue perfusion to determine shock status. Capillary refill time is defined as the time required to regain skin color after blanching pressure is applied. Although common methods to measure capillary refill time depend on clinicians' visual assessment, a new approach using a pulse oximeter waveform analysis exists, referred to as full finger reperfusion time. We aim to evaluate reproducibility and validity of the novel full finger reperfusion time measurement using clinicians' visual capillary refill time assessment as a reference standard.

designProspective observational study.

settingPICUs and operating suites at a large academic children's hospital. PATIENTS: Ninety-nine children 1-12 years old with various skin color tones.

interventionsEach child had 10 measurements, including five full finger reperfusion time and five clinician capillary refill time, alternating second and third digits. MEASUREMENTS AND MAIN

resultsEighteen children had prolonged capillary refill time (> 2 s) and four children with capillary refill time greater than 3 seconds. Four-hundred eighty-five data pairs were analyzed. Intraclass correlation coefficient of full finger reperfusion time within each patient was 0.76 (95% CI, 0.68-0.83), demonstrating good reproducibility. Correlation coefficient between full finger reperfusion time and clinician capillary refill time was moderate: r = 0.37 (p < 0.0001; 95% CI, 0.29-0.44) for the pairs and r = 0.52 (p < 0.0001; 95% CI, 0.36-0.65) for patient average. Bland-Altman plot showed a consistent difference between full finger reperfusion time and clinician capillary refill time (full finger reperfusion time 1.14 s longer). Weak association was found between force and full finger reperfusion time (β = -0.033 ± 0.016; 95% CI, -0.065 to -0.0016; p = 0.04), finger thickness (β = -0.20 ± 0.089; 95% CI, -0.37 to -0.19; p = 0.03), except for color tone (p = 0.31). Finger temperature was associated with full finger reperfusion time (β = -0.18 ± 0.041; 95% CI, -0.26 to -0.0999; p < 0.0001).

conclusionsFull finger reperfusion time demonstrated good reproducibility. Full finger reperfusion time showed moderate correlation with clinician capillary refill time. Full finger reperfusion time was 1.14 seconds longer than capillary refill time. Future studies should focus on the clinical value of full finger reperfusion time as a monitoring device for hemodynamics in critically ill children.

Indexed as

Intensive Care Units, PediatricChildChild, PreschoolFemaleFingersHemodynamicsHospitals, PediatricHumansInfantMaleOximetryProspective StudiesReproducibility of ResultsShockSkin

Identifiers

PMID32701550
PMCPMC7888558
OpenAlexW3044289225

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.